Listando por materia "57"
Mostrando ítems 1-20 de 45
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2P-111 Stochastic resonance in DNA hairpins(The 46th Annual Meeting of the Biophysical Society of Japan)
(Seibutsu Butsuri, 2008) -
The ADP-ribose hydrolase NUDT5 is important for DNA repair
(Cell Reports, 2022-12)DNA damage leads to rapid synthesis of poly(ADP-ribose) (pADPr), which is important for damage signaling and repair. pADPr chains are removed by poly(ADP-ribose) glycohydrolase (PARG), releasing free ... -
ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling
(Science, 2016)Key nuclear processes in eukaryotes, including DNA replication, repair, and gene regulation, require extensive chromatin remodeling catalyzed by energy-consuming enzymes. It remains unclear how the ATP ... -
An analysis of the ethics of principles, 40 years later
(Revista Bioética, 2018)La Bioética de principios se ha convertido en un paradigma de la valoración moral en la práctica clínica. La estructuración en cuatro principios (autonomía, beneficencia, no maleficencia y justicia), ... -
Caracterización molecular de nuevos substratos de la CDK Pho85
(Fecha de defensa: 2013-07-29)La ciclina Cln3 es un activador crítico de START, cuya sobreexpresión provoca células de menor tamaño que progresan rápidamente por el ciclo celular, mientras que su deleción induce un mayor tamaño de ... -
Chronic full-band recordings with graphene microtransistors as neural interfaces for discrimination of brain states
(Nanoscale Horizons, 2024)Brain states such as sleep, anesthesia, wakefulness, or coma are characterized by specific patterns of cortical activity dynamics, from local circuits to full-brain emergent properties. We previously ... -
Derivation of nearest-neighbor DNA parameters in magnesium from single molecule experiments
(Nucleic Acids Research, 2017)DNA hybridization is an essential molecular reaction in biology with many applications. The nearest-neighbor (NN) model for nucleic acids predicts DNA thermodynamics using energy values for the different ... -
Dynamic force spectroscopy of DNA hairpins: I. Force kinetics and free energy landscapes
(Journal of Statistical Mechanics: Theory and Experiment, 2009)We investigate the thermodynamics and kinetics of DNA hairpins that fold/unfold under the action of applied mechanical force. We introduce the concept of the molecular free energy landscape and derive ... -
Dynamic force spectroscopy of DNA hairpins: II. Irreversibility and dissipation
(Journal of Statistical Mechanics: Theory and Experiment, 2009)We investigate irreversibility and dissipation in single molecules that cooperatively fold/unfold in a two-state manner under the action of mechanical force. We apply path thermodynamics to derive ... -
Engineering a genome-reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo
(Molecular Systems Biology, 2021)Bacteria present a promising delivery system for treating human diseases. Here, we engineered the genome-reduced human lung pathogen Mycoplasma pneumoniae as a live biotherapeutic to treat biofilm-associated ... -
Functional characterization of a novel non-coding mutation “Ghent +49A > G” in the iron-responsive element of L-ferritin causing hereditary hyperferritinaemia-cataract syndrome
(Scientific Reports, 2017)Hereditary hyperferritinaemia-cataract syndrome (HHCS) is a rare disorder usually caused by heterozygous mutations in the iron-responsive element (IRE) in the 5′ untranslated region (5′UTR) of the ... -
Functional consequences of transferrin receptor-2 mutations causing hereditary hemochromatosis type 3
(Molecular Genetics & Genomic Medicine, 2015)Hereditary hemochromatosis (HH) type 3 is an autosomal recessive disorder of iron metabolism characterized by excessive iron deposition in the liver and caused by mutations in the transferrin receptor ... -
Hormone-induced repression of genes requires BRG1-mediated H1.2 deposition at target promoters
(The EMBO Journal, 2016)Eukaryotic gene regulation is associated with changes in chromatin compaction that modulate access to DNA regulatory sequences relevant for transcriptional activation or repression. Although much is ... -
Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition
(Journal of Biological Chemistry, 2003-03-14)Carnitine palmitoyltransferase (CPT) I, which catalyzes the conversion of palmitoyl-CoA to palmitoylcarnitine facilitating its transport through the mitochondrial membranes, is inhibited by malonyl-CoA. ... -
Impedimetric antimicrobial peptide-based sensor for the early detection of periodontopathogenic bacteria
(Biosensors and Bioelectronics, 2016-12-15)Peri-implantitis, an inflammation caused by biofilm formation, constitutes a major cause of implant failure in dentistry. Thus, the detection of bacteria at the early steps of biofilm growth represents ... -
Investigating the thermodynamics of small biosystems with optical tweezers
(Physica E: Low-dimensional Systems and Nanostructures, 2010)We present two examples of how single-molecule experimental techniques applied to biological systems can give insight into problems within the scope of equilibrium and nonequilibrium mesoscopic ... -
Iron Regulation and the Cell Cycle: identification of an iron-responsive element in the 3′-untranslated region of human cell division cycle 14a mrna by a refined microarray-based screening strategy
(The Journal of Biological Chemistry, 2006)Iron regulatory proteins (IRPs) 1 and 2 post-transcriptionally control mammalian iron homeostasis by binding to iron-responsive elements (IREs), conserved RNA stem-loop structures located in the 5′- or ... -
The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays
(BMC Bioinformatics, 2010)Background: Gene expression studies greatly contribute to our understanding of complex relationships in gene regulatory networks. However, the complexity of array design, production and manipulations ... -
La ciclina CNTD2: un nuevo inductor del desarrollo tumoral
(Fecha de defensa: 2018-07-26)El cáncer colorrectal (CRC) es uno de los cánceres más comunes en todo el mundo, con un 8-10% de estos tumores que presentan una mutación BRAF (V600E). Las ciclinas son oncogenes comúnmente desregulados ... -
LoxTnSeq: random transposon insertions combined with cre/lox recombination and counterselection to generate large random genome reductions
(Microbial Biotechnology, 2021)The removal of unwanted genetic material is a key aspect in many synthetic biology efforts and often requires preliminary knowledge of which genomic regions are dispensable. Typically, these efforts are ...