Effectiveness of airway clearance techniques versus control in non-hospitalized infants with moderate acute viral bronchiolitis: A randomized controlled clinical trial
Autor/a
Data de publicació
2025-08-04ISSN
1807-5932
Resum
Background: Acute viral bronchiolitis is the most common lower respiratory tract infection in infants < 2-years of
age. Airway Clearance Techniques (ACTs) aim to reduce airway obstruction, thereby decreasing airway resistance, improving gas exchange, and reducing respiratory load, all of which can lead to improved clinical
stability.
Methods: One hundred ninety-two infants were randomly allocated to one of the following ACTs using flow-based
techniques: Assisted Autogenic Drainage (AAD; n = 62), Prolonged Slow Expiration (PSE; n = 63), or a control
group (n = 67). The sessions were performed in an outpatient setting, with a duration of 20 min and repeated 48
h later. The outcome measures were the Acute Bronchiolitis Severity Scale (ABSS), Bronchiolitis Score of Sant
Joan de D´eu (BROSJOD), and peripheral oxygen saturation (SpO2) recorded immediately after each intervention.
Results: Both airway clearance techniques, PSE and AAD, demonstrated significant improvements in clinical
severity scores (ABSS and BROSJOD) and SpO2 levels compared to the control group, with PSE showing the most
pronounced effects. ABSS (ATSboot p = 0.001; η2
p = 0.105) and BROSJOD (ATSboot p = 0.003; η2
p=0.037)
significantly differed and interacted with time, decreasing from baseline to 48 h post-treatment. PSE outperformed the controls in reducing ABSS (p < 0.001; Hedges’ g = 1.4 vs. g = 0.37). ACTs improved ABSS and
BROSJOD scores compared to controls, with PSE showing the greatest SpO2 increase and wheezing reduction at
20 minutes and one hour post-baseline. At 48 h, the AAD and PSE groups had greater ABSS changes than the
controls and fewer retractions at 20 min post-baseline. The AAD group had a lower heart rate, while the controls
had higher respiratory rates, and the PSE group had the lowest heart rate. No significant clinical adverse effects
were observed.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
Anglès
Matèries (CDU)
616.7 - Patologia dels òrgans de la locomoció. Sistema locomotor i esquelètic
Paraules clau
Pàgines
9
Publicat per
Elsevier
Col·lecció
80; 100735
Publicat a
Official Scientific Journal of Faculdade de Medicina and Hospital das Clínicas
Citació
González-Bellido, Vanesa; Rama Suárez, Noelia; Yánez Yepez, Gustavo Adolfo[et al.]. Effectiveness of airway clearance techniques versus control in non-hospitalized infants with moderate acute viral bronchiolitis: A randomized controlled clinical trial. Official Scientific Journal of Faculdade de Medicina and Hospital das Clínicas, 2025, 80, 100735. Disponible en <https://pmc.ncbi.nlm.nih.gov/articles/PMC12374053/>. Fecha de acceso: 28 oct. 2025. DOI: 10.1016/j.clinsp.2025.100735
Nota
MVFD was financed in part by Coordenaçao ˜ de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001, and Conselho Nacional de Desenvolvimento Científico e Tecnologico ´ (CNPq).
Aquest element apareix en la col·lecció o col·leccions següent(s)
- Ciències de la Salut [960]
Drets
/© 2025 HCFMUSP. Published by Elsevier España, S.L.U. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com http://creativecommons.org/licenses/by/4.0/


