Genomic characterization of invasive Neisseria meningitidis in Spain (2011/12–2022/23): expansion of clonal complex 213 and the potential threat to 4CMenB vaccine strain coverage
Author
Publication date
2025ISSN
2222-1751
Abstract
Invasive meningococcal disease (IMD) is associated with significant global morbidity and mortality and is addressed by conjugated polysaccharide and subcapsular vaccines. In Spain, data on 4CMenB vaccine strain coverage and antimicrobial susceptibility are limited. This study aimed to describe the genomic epidemiology, predict 4CMenB vaccine strain coverage, and assess antimicrobial susceptibility of 323 Neisseria meningitidis isolates causing IMD, collected from 57 Clinical Microbiology Laboratories in Spain over 12 years (2011/12–2022/23). Whole genome sequencing was performed to identify serogroup, clonal complex (cc), and antimicrobial resistance determinants. Vaccine strain coverage for serogroup B (MenB) isolates was predicted using the genetic Meningococcal Antigen Typing System approach. The most prevalent serogroups were B (57.9%), W (21.4%), C (10.4%), and Y (8.4%). MenB predominated throughout most seasons, except during the 2019/20 season when serogroup W peaked. Post-COVID-19 pandemic, MenB remained the most frequent (70.2%). Thirteen cc were identified among MenB isolates, with cc213 being the most prevalent (40.1%). Only 28.9% of MenB isolates were predicted to be covered by 4CMenB, with cc213 showing an exceptionally low coverage rate (5.3%) due to antigenic variants poorly targeted by the vaccine. Notably, cc213 was responsible for twice the proportion of MenB cases in 4CMenB-vaccinated versus unvaccinated. All isolates were susceptible to third generation cephalosporins, and 13.5% showed penicillin resistance. This study highlights the alarming prevalence of cc213 among MenB IMD cases in Spain and the limited 4CMenB coverage against this cc. The disproportionate representation of cc213 in vaccinated individuals underscores its potential to compromise vaccine effectiveness.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
57 - Biological sciences in general
Keywords
Pages
15
Publisher
Taylor & Francis
Collection
14
Is part of
Emerging Microbes & Infections
Citation
Roca-Grande, Josep; Mir-Cros, Alba; Muñoz-Almagro, Carmen [et al.]. Genomic characterization of invasive Neisseria meningitidis in Spain (2011/12–2022/23): expansion of clonal complex 213 and the potential threat to 4CMenB vaccine strain coverage. Emerging Microbes & Infections, 2025, 14(1), 2482696. Disponible en: <https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2482696?scroll=top&needAccess=true#abstract>. Fecha de acceso: 7 may. 2025. DOI: 10.1080/22221751.2025.2482696
Note
This work was supported by the “Instituto de Salud Carlos III” and cofinanced by the European Regional Development Fund (ERDF) grant number FIS PI21/00132, and by the “Centro de Investigación Biomédica en Red” (CIBER de Enfermedades Infecciosas) grant number CB21/13/00054.
This item appears in the following Collection(s)
- Ciències de la Salut [952]
Rights
© 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., LtdThis is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), whichpermits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has beenpublished allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc/4.0/