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dc.contributor.authorGómez, Silvia G.
dc.contributor.authorBoix-Lemonche, Gerard
dc.contributor.authorOrrit-Prat, Jordi
dc.contributor.authorBonet, Raül
dc.contributor.authorCARO, JAUME
dc.contributor.authorMuñoz, Joan
dc.contributor.authorGinebra, Maria-Pau
dc.contributor.authorSKERLAVAJ, Barbara
dc.contributor.authorBarraquer, Rafael I
dc.contributor.authorManero, José María
dc.date.accessioned2025-04-04T13:45:30Z
dc.date.available2025-04-04T13:45:30Z
dc.date.issued2025
dc.identifier.citationGómez, Silvia G.; Boix-Lemonche, Gerard; Orrit-Prat, Jordi [et al.]. Synergistic dual Ag/Cu ion implantation to enhance antimicrobial defense on boston keratoprosthesis. Biomaterials Research, 2025, 29, 0147. Disponible en: <https://spj.science.org/doi/10.34133/bmr.0147>. Fecha de acceso: 4 abr. 2025. DOI: 10.34133/bmr.0147ca
dc.identifier.issn1226-4601ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/4850
dc.descriptionThe authors thank the Spanish State Research Agency for financial support (project PID 2021-125150OB-I00 and project PDC2022-133628-C21). They also thank the Generalitat de Catalunya (FI-AGAUR grant 2023 FI-3 00210 to S.G.G.). M.P.G. acknowledges the ICREA Academia award from the Generalitat de Catalunya. This work has been partially funded by the Ministry of Science and Innovation of Spain (project EQUIDENTAL (CPP2022-009563)). This work is part of the Maria de Maeztu Units of Excellence Programme (CEX2023-001300-M/ funded by MCIN/AEI/ 0.13039/501100011033).
dc.description.abstractThe Boston keratoprosthesis (BKPro) is a critical device for vision restoration in complex cases of corneal blindness, although its long-term retention is challenged by infection risks. This study aims to enhance the antimicrobial properties of the titanium (Ti) backplate of the BKPro by ion implanting silver and copper ions to achieve effective infection control while maintaining cytocompatibility. Research on antimicrobial modifications for BKPro is limited, and while metallic ions like Ag and Cu show promise for biomaterial improvement, their effects on human corneal keratocytes (HCKs) require further study. Ag and Cu were implanted onto rough Ti surfaces, as mono- and coimplantations. Cytotoxicity was assessed in HCKs, and antimicrobial efficacy was tested against Pseudomonas aeruginosa and Candida albicans. After 21 d, monoimplanted Ag samples released 300.4 ppb of Ag+, coimplanted samples released 427.5 ppb of Ag+ and 272.3 ppb of Cu ions, and monoimplanted Cu samples released 567.0 ppb of Cu ions. All ion-implanted surfaces supported HCK proliferation, exhibited no cytotoxicity, and showed strong antimicrobial activity. Ag-implanted surfaces provided antibacterial effects through membrane disruption and reactive oxygen species generation, while Cu-implanted surfaces exhibited antifungal effects via impaired enzymatic functions and reactive oxygen species. Coimplanted AgCu surfaces demonstrated synergistic antimicrobial effects, resulting from the synergy between the bactericidal actions of Ag and the oxidative stress contributions of Cu. Additionally, ion-implanted surfaces enhanced HCK adhesion under co-culture conditions. In conclusion, ion implantation effectively imparts antimicrobial properties to the Ti backplate of BKPro, reducing infection risks while preserving compatibility with corneal cells.ca
dc.format.extent16ca
dc.language.isoengca
dc.publisherAmerican Association for the Advancement of Scienceca
dc.relation.ispartofBiomaterials Researchca
dc.relation.ispartofseries29
dc.rights© 2025 Silvia G. Gómez et al. Exclusive licensee Korean Society for Biomaterials, Republicof Korea. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License (CC BY 4.0).ca
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.otherDefensa antimicrobianaca
dc.subject.otherQueratoprótesis de Bostonca
dc.subject.otherDefensa antimicrobianaca
dc.subject.otherQueratopròtesi de Bostonca
dc.subject.otherAntimicrobial Defenseca
dc.subject.otherBoston Keratoprosthesisca
dc.titleSynergistic dual Ag/Cu ion implantation to enhance antimicrobial defense on boston keratoprosthesisca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc61ca
dc.identifier.doihttps://dx.doi.org/10.34133/bmr.0147ca


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© 2025 Silvia G. Gómez et al. Exclusive licensee Korean Society for Biomaterials, Republicof Korea. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License (CC BY 4.0).
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