dc.contributor.author | Carballo-Márquez, Anna | |
dc.contributor.author | Vale-Martínez, Anna | |
dc.contributor.author | Guillazo-Blanch, Gemma | |
dc.contributor.author | Torras-Garcia, Meritxell | |
dc.contributor.author | Boix-Trelis, Núria | |
dc.contributor.author | Martí-Nicolovius, Margarita | |
dc.date.accessioned | 2024-02-12T11:57:33Z | |
dc.date.available | 2024-02-12T11:57:33Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | Carballo-Márquez, Anna; Vale-Martínez, Anna; Guillazo-Blanch, Gemma [et al.]. Differential effects of muscarinic receptor blockade in prelimbic cortex on acquisition and memory formation of an odor-reward task. Learning Memory, 2007, 14, p. 616-624. Disponible en: <https://learnmem.cshlp.org/content/14/9/616>. Fecha de acceso: 12 feb. 2024. DOI: 10.1101/lm.597507 | ca |
dc.identifier.issn | 1072-0502 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/4083 | |
dc.description.abstract | The present experiments determined the consequences of blocking muscarinic cholinergic receptors of the prelimbic (PL) cortex in the acquisition and retention of an odor-reward associative task. Rats underwent a training test (five trials) and a 24-h retention test (two retention trials and two relearning trials). In the first experiment, rats were bilaterally infused with scopolamine (20 or 5 μg/site) prior to training. Although scopolamine rats showed acquisition equivalent to PBS-injected controls, they exhibited weakened performance in the 24-h retention test measured by number of errors. In the second experiment, rats were injected with scopolamine (20 μg/site) immediately or 1 h after training and tested 24 h later. Scopolamine rats injected immediately showed severe amnesia detected in two performance measures (errors and latencies), demonstrating deficits in retention and relearning, whereas those injected 1 h later showed good 24-h test performance, similar to controls. These results suggest that muscarinic transmission in the PL cortex is essential for early memory formation, but not for acquisition, of a rapidly learned odor discrimination task. Findings corroborate the role of acetylcholine in consolidation processes and the participation of muscarinic receptors in olfactory associative tasks. | ca |
dc.format.extent | 8 | ca |
dc.language.iso | eng | ca |
dc.publisher | Cold Spring Harbor Laboratory Press | ca |
dc.relation.ispartof | Learning Memory | ca |
dc.relation.ispartofseries | 14 | |
dc.rights | © 2007, Cold Spring Harbor Laboratory Press | ca |
dc.subject.other | Memòria | ca |
dc.subject.other | Memoria | ca |
dc.subject.other | Memory | ca |
dc.title | Differential effects of muscarinic receptor blockade in prelimbic cortex on acquisition and memory formation of an odor-reward task | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 159.9 | ca |
dc.identifier.doi | https://dx.doi.org/10.1101/lm.597507 | ca |