Differential effects of muscarinic receptor blockade in prelimbic cortex on acquisition and memory formation of an odor-reward task
Autor/a
Carballo-Márquez, Anna
Vale-Martínez, Anna
Guillazo-Blanch, Gemma
Torras-Garcia, Meritxell
Boix-Trelis, Núria
Martí-Nicolovius, Margarita
Data de publicació
2007ISSN
1072-0502
Resum
The present experiments determined the consequences of blocking muscarinic cholinergic receptors of the prelimbic (PL) cortex in the acquisition and retention of an odor-reward associative task. Rats underwent a training test (five trials) and a 24-h retention test (two retention trials and two relearning trials). In the first experiment, rats were bilaterally infused with scopolamine (20 or 5 μg/site) prior to training. Although scopolamine rats showed acquisition equivalent to PBS-injected controls, they exhibited weakened performance in the 24-h retention test measured by number of errors. In the second experiment, rats were injected with scopolamine (20 μg/site) immediately or 1 h after training and tested 24 h later. Scopolamine rats injected immediately showed severe amnesia detected in two performance measures (errors and latencies), demonstrating deficits in retention and relearning, whereas those injected 1 h later showed good 24-h test performance, similar to controls. These results suggest that muscarinic transmission in the PL cortex is essential for early memory formation, but not for acquisition, of a rapidly learned odor discrimination task. Findings corroborate the role of acetylcholine in consolidation processes and the participation of muscarinic receptors in olfactory associative tasks.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
159.9 - Psicologia
Paraules clau
Memòria
Memoria
Memory
Pàgines
8
Publicat per
Cold Spring Harbor Laboratory Press
Col·lecció
14
Publicat a
Learning Memory
Citació
Carballo-Márquez, Anna; Vale-Martínez, Anna; Guillazo-Blanch, Gemma [et al.]. Differential effects of muscarinic receptor blockade in prelimbic cortex on acquisition and memory formation of an odor-reward task. Learning Memory, 2007, 14, p. 616-624. Disponible en: <https://learnmem.cshlp.org/content/14/9/616>. Fecha de acceso: 12 feb. 2024. DOI: 10.1101/lm.597507
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Drets
© 2007, Cold Spring Harbor Laboratory Press