Combined aerobic exercise and high-intensity respiratory muscle training in patients surgically treated for non-small cell lung cancer: a pilot randomized clinical trial
Author
Messaggi-Sartor, Monique
Marco, Ester
Martínez-Téllez, Elisabeth
Rodriguez-Fuster, Alberto
Palomares, Carolina
Chiarella, Sandra
Muniesa, Josep M.
Orozco-Levi, Mauricio
Barreiro, Esther
Güell, Maria R
Publication date
2019ISSN
1973-9087
Abstract
BACKGROUND: Lung resection surgery further decreases exercise capacity and negatively affects respiratory muscle function in patients with non-small cell lung cancer (NSCLC). The best design for exercise interventions in these patients has not been determined yet. AIM: To assess the impact of aerobic exercise and high-intensity respiratory muscle training on patient outcomes following lung cancer resection surgery. DESIGN: Prospective, single-blind, pilot randomized controlled trial. SETTING: Outpatient cardiopulmonary rehabilitation unit of two university hospitals. POPULATION: Thirty-seven patients with NSCLC after tumor resection. METHODS: Patients were randomly assigned to exercise training or usual post-operative care. The training program consisted of aerobic exercises and high-intensity respiratory muscle training (24 supervised sessions, 3 per week, 8 weeks). Primary outcome was exercise capacity assessed with peak oxygen uptake (VO2peak) during cardiopulmonary exercise test. Secondary outcomes included changes in respiratory muscle strength, levels of serum insulin growth factor I (IGF-I) and IGF binding protein 3 (IGFBP-3), and quality of life assessed with the European Organization for Research and Treatment of Cancer (EORTC QLQ-C30) questionnaire. RESULTS: The 8-week training program was associated with significant improvement in VO2peak (2.13 mL/Kg/min [95%CI 0.06 to 4.20]), maximal inspiratory and expiratory pressures (18.96 cmH2O [95% CI 2.7 to 24.1] and 18.58 cmH2O [95% CI 4.0 to 33.1], respectively) and IGFBP-3 (0.61 µg/mL [%95 CI 0.1 to 1.12]). No significant differences were observed in the EORTC QLQ-C30. CONCLUSIONS: An 8-week exercise program consisting of aerobic exercise and high-intensity respiratory muscle training improved exercise capacity, respiratory muscle strength, and serum IGFBP-3 levels in NSCLC patients after lung resection. There was no impact on the other outcomes assessed. CLINICAL REHABILITATION IMPACT: A combination of aerobic exercise and respiratory muscle training could be included in the rehabilitation program of deconditioned patients with NSCLC after lung resection surgery.
Document Type
Article
Document version
Published version
Language
English
Keywords
Neoplàsies pulmonars
Aptitud cardiorespiratòria
Exercicis de respiració
Rehabilitació
Neoplasias pulmonares
Fitness cardiorrespiratorio
Ejercicios de respiración
Rehabilitación
Lung neoplasms
Cardiorespiratory fitness
Breathing exercises
Rehabilitation
Pages
10
Publisher
Edizioni Minerva Medica
Collection
55; 1
Is part of
European Journal of Physical and Rehabilitation Medicine
Citation
Messaggi-Sartor, Monique; Marco, Ester; Martínez-Téllez, Elisabeth [et al.]. Combined aerobic exercise and high-intensity respiratory muscle training in patients surgically treated for non-small cell lung cancer: a pilot randomized clinical trial. European Journal of Physical and Rehabilitation Medicine, 2018, 55(1), p. 113-122. Disponible en: <https://www.minervamedica.it/en/journals/europa-medicophysica/article.php?cod=R33Y2019N01A0113>. Fecha de acceso: 26 ene. 2024. DOI: 10.23736/S1973-9087.18.05156-0
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Rights
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