A 3-dimensional histology computer model of malignant melanoma and its implications for digital pathology
Author
Kurz, Alexander
Krahl, Dieter
Kutzner, Heinz
Barnhill, Raymond
Perasole, Antonio
Fernandez Figueras, Maria Teresa
Ferrara, Gerardo
Braun, Stephan A.
Starz, Hans
Llamas-Velasco, Mar
Sven Utikal, Jochen
Fröhling, Stefan
von Kalle, Christof
Kather, Jakob Nikolas
Schneider, Lucas
Brinker, Titus J.
Publication date
2023ISSN
0959-8049
Abstract
Background: Historically, cancer diagnoses have been made by pathologists using two-dimensional histological slides. However, with the advent of digital pathology and artificial intelligence, slides are being digitised, providing new opportunities to integrate their information. Since nature is 3-dimensional (3D), it seems intuitive to digitally reassemble the 3D structure for diagnosis. Objective: To develop the first human-3D-melanoma-histology-model with full data and code availability. Further, to evaluate the 3D-simulation together with experienced pathologists in the field and discuss the implications of digital 3D-models for the future of digital pathology. Methods: A malignant melanoma of the skin was digitised via 3 µm cuts by a slide scanner; an open-source software was then leveraged to construct the 3D model. A total of nine pathologists from four different countries with at least 10 years of experience in the histologic diagnosis of melanoma tested the model and discussed their experiences as well as implications for future pathology. Results: We successfully constructed and tested the first 3D-model of human melanoma. Based on testing, 88.9% of pathologists believe that the technology is likely to enter routine pathology within the next 10 years; advantages include a better reflectance of anatomy, 3D assessment of symmetry and the opportunity to simultaneously evaluate different tissue levels at the same time; limitations include the high consumption of tissue and a yet inferior resolution due to computational limitations. Conclusions: 3D-histology-models are promising for digital pathology of cancer and melanoma specifically, however, there are yet limitations which need to be carefully addressed.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
616.5 - Skin. Common integument. Clinical dermatology. Cutaneous complaints
Keywords
Dermatologia
Patologia digital
Dermatopatologia
Melanoma
Intel·ligència artificial
Aprenentatge profund
Dermatología
Patología digital
Dermatopatología
Melanoma
Inteligencia artificial
Aprendizaje profundo
Dermatology
Digital pathology
Dermatopathology
Melanoma
Artificial intelligence
Deep learning
Pages
7
Publisher
Elsevier
Collection
193
Is part of
European Journal of Cancer
Citation
Kurz, Alexander; Krahl, Dieter; Kutzner, Heinz [et al.]. A 3-dimensional histology computer model of malignant melanoma and its implications for digital pathology. European Journal of Cancer, 2023, 193, 113294. Disponible en: <https://www.ejcancer.com/article/S0959-8049(23)00396-9/fulltext>. Fecha de acceso: 7 nov. 2023. DOI: 10.1016/j.ejca.2023.113294
This item appears in the following Collection(s)
- Ciències de la Salut [725]
Rights
© 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/