Mostra el registre parcial de l'element
Alterations in p53, microsatellite stability and lack of MUC5AC expression as molecular features of colorectal carcinoma associated with inflammatory bowel disease
dc.contributor.author | Hijós, Míriam Gené | |
dc.contributor.author | Cuatrecasas, Miriam | |
dc.contributor.author | Amat, Irene | |
dc.contributor.author | VEIGA BARREIRO, JESUS ALBERTO | |
dc.contributor.author | Fernández-Aceñero, Mª Jesús | |
dc.contributor.author | Fusté Chimisana, Victòria | |
dc.contributor.author | Tarragona, Jordi | |
dc.contributor.author | Jurado, Ismael | |
dc.contributor.author | Fernández-Victoria, Rebeca | |
dc.contributor.author | Martínez Ciarpaglini, Carolina | |
dc.contributor.author | Alenda, Cristina | |
dc.contributor.author | Zac, Carlos | |
dc.contributor.author | Ortega de la Obra, Pilar | |
dc.contributor.author | Fernández-Figueras, María Teresa | |
dc.contributor.author | Esteller, Manel | |
dc.contributor.author | Musulen, Eva | |
dc.date.accessioned | 2023-06-21T10:25:29Z | |
dc.date.available | 2023-06-21T10:25:29Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Gené Hijós, Míriam; Cuatrecasas, Miriam; Amat, Irene [et al.]. Alterations in p53, microsatellite stability and lack of MUC5AC expression as molecular features of colorectal carcinoma associated with inflammatory bowel disease. International Journal of Molecular Sciences, 2023, 24(10), 8655. Disponible en: <https://www.mdpi.com/1422-0067/24/10/8655>. Fecha de acceso: 21 jun. 2023. DOI: 10.3390/ijms24108655 | ca |
dc.identifier.issn | 1422-0067 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/3735 | |
dc.description.abstract | Colitis-associated colorectal carcinoma (CAC) occurs in inflammatory bowel disease (IBD) because of the “chronic inflammation-dysplasia-cancer” carcinogenesis pathway characterized by p53 alterations in the early stages. Recently, gastric metaplasia (GM) has been described as the initial event of the serrated colorectal cancer (CRC) process, resulting from chronic stress on the colon mucosa. The aim of the study is to characterize CAC analyzing p53 alterations and microsatellite instability (MSI) to explore their relationship with GM using a series of CRC and the adjacent intestinal mucosa. Immunohistochemistry was performed to assess p53 alterations, MSI and MUC5AC expression as a surrogate for GM. The p53 mut-pattern was found in more than half of the CAC, most frequently stable (MSS) and MUC5AC negative. Only six tumors were unstable (MSI-H), being with p53 wt-pattern (p = 0.010) and MUC5AC positive (p = 0.005). MUC5AC staining was more frequently observed in intestinal mucosa, inflamed or with chronic changes, than in CAC, especially in those with p53 wt-pattern and MSS. Based on our results, we conclude that, as in the serrated pathway of CRC, in IBD GM occurs in inflamed mucosa, persists in those with chronic changes and disappears with the acquisition of p53 mutations. | en |
dc.format.extent | 17 | ca |
dc.language.iso | eng | ca |
dc.publisher | MDPI | ca |
dc.relation.ispartof | International Journal of Molecular Sciences | ca |
dc.relation.ispartofseries | 24;10 | |
dc.relation.uri | https://www.mdpi.com/1422-0067/24/10/8655 | ca |
dc.rights | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Malaltia intestinal intestinal | ca |
dc.subject.other | Càncer de colon | ca |
dc.subject.other | Expressió MUC5AC | ca |
dc.subject.other | Metaplàsia gàstrica | ca |
dc.subject.other | Resposta al dany de l'ADN | ca |
dc.subject.other | Enfermedad del intestino intestinal | es |
dc.subject.other | Cáncer colonrectal | es |
dc.subject.other | Expresión de MUC5AC | es |
dc.subject.other | Metaplasia gástrica | es |
dc.subject.other | Respuesta al daño del ADN | es |
dc.subject.other | Intestinal bowel disease | en |
dc.subject.other | Colorectal cancer | en |
dc.subject.other | MUC5AC expression | en |
dc.subject.other | Gastric metaplasia | en |
dc.subject.other | DNA-damage response | en |
dc.title | Alterations in p53, microsatellite stability and lack of MUC5AC expression as molecular features of colorectal carcinoma associated with inflammatory bowel disease | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 61 | ca |
dc.identifier.doi | https://dx.doi.org/10.3390/ijms24108655 | ca |
Fitxers en aquest element
Aquest element apareix en la col·lecció o col·leccions següent(s)
-
Ciències de la Salut [738]