Alterations in p53, microsatellite stability and lack of MUC5AC expression as molecular features of colorectal carcinoma associated with inflammatory bowel disease
Autor/a
Amat, Irene
Fusté Chimisana, Victòria
Jurado, Ismael
Fernández-Victoria, Rebeca
Martínez Ciarpaglini, Carolina
Zac, Carlos
Ortega de la Obra, Pilar
Fernández-Figueras, María Teresa
Data de publicació
2023ISSN
1422-0067
Resum
Colitis-associated colorectal carcinoma (CAC) occurs in inflammatory bowel disease (IBD) because of the “chronic inflammation-dysplasia-cancer” carcinogenesis pathway characterized by p53 alterations in the early stages. Recently, gastric metaplasia (GM) has been described as the initial event of the serrated colorectal cancer (CRC) process, resulting from chronic stress on the colon mucosa. The aim of the study is to characterize CAC analyzing p53 alterations and microsatellite instability (MSI) to explore their relationship with GM using a series of CRC and the adjacent intestinal mucosa. Immunohistochemistry was performed to assess p53 alterations, MSI and MUC5AC expression as a surrogate for GM. The p53 mut-pattern was found in more than half of the CAC, most frequently stable (MSS) and MUC5AC negative. Only six tumors were unstable (MSI-H), being with p53 wt-pattern (p = 0.010) and MUC5AC positive (p = 0.005). MUC5AC staining was more frequently observed in intestinal mucosa, inflamed or with chronic changes, than in CAC, especially in those with p53 wt-pattern and MSS. Based on our results, we conclude that, as in the serrated pathway of CRC, in IBD GM occurs in inflamed mucosa, persists in those with chronic changes and disappears with the acquisition of p53 mutations.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
Anglès
Matèries (CDU)
61 - Medicina
Paraules clau
Malaltia intestinal intestinal
Càncer de colon
Expressió MUC5AC
Metaplàsia gàstrica
Resposta al dany de l'ADN
Enfermedad del intestino intestinal
Cáncer colonrectal
Expresión de MUC5AC
Metaplasia gástrica
Respuesta al daño del ADN
Intestinal bowel disease
Colorectal cancer
MUC5AC expression
Gastric metaplasia
DNA-damage response
Pàgines
17
Publicat per
MDPI
Col·lecció
24;10
Publicat a
International Journal of Molecular Sciences
Citació
Gené Hijós, Míriam; Cuatrecasas, Miriam; Amat, Irene [et al.]. Alterations in p53, microsatellite stability and lack of MUC5AC expression as molecular features of colorectal carcinoma associated with inflammatory bowel disease. International Journal of Molecular Sciences, 2023, 24(10), 8655. Disponible en: <https://www.mdpi.com/1422-0067/24/10/8655>. Fecha de acceso: 21 jun. 2023. DOI: 10.3390/ijms24108655
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Drets
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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