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Evaluation of plasma lipocalin-2 as a predictor of etiology and severity in adult patients with community-acquired pneumonia
dc.contributor.author | Boix-Palop, Lucía | |
dc.contributor.author | Vergara, Andrea | |
dc.contributor.author | Padilla, Emma | |
dc.contributor.author | Martínez, Diego | |
dc.contributor.author | Blanco, Ana | |
dc.contributor.author | Pérez, Josefa | |
dc.contributor.author | Calbo, Esther | |
dc.contributor.author | Vila, Jordi | |
dc.contributor.author | Casals-Pascual, Climent | |
dc.date.accessioned | 2023-06-21T09:56:26Z | |
dc.date.available | 2023-06-21T09:56:26Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Boix-Palop, Lucía; Vergara, Andrea; Padilla, Emma [et al.]. Evaluation of plasma lipocalin-2 as a predictor of etiology and severity in adult patients with community-acquired pneumonia. Microorganisms, 2023, 11(5), 1160. Disponible en: <https://www.mdpi.com/2076-2607/11/5/1160>. Fecha de acceso: 21 jun. 2023. DOI: 10.3390/microorganisms11051160 | ca |
dc.identifier.issn | 2076-2607 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/3734 | |
dc.description.abstract | The aim of this study was to evaluate the diagnostic performance of plasma Lipocalin-2 (LCN2) concentration in adult patients with community-acquired pneumonia (CAP) to determine its etiology, severity and prognosis. A prospective observational study involving adults with CAP from November 2015 to May 2017 was conducted. Plasma LCN2 concentration was measured upon admission by a modified enzyme immunoassay coupled with chemiluminescence (Architect, Abbott Laboratories). The diagnostic performance of LCN2, C-reactive protein (CRP) and white blood cell to predict bacterial CAP was assessed. A total of 130 patients with CAP were included: 71 (54.6%) bacterial CAP, 42 (32.3%) unknown origin CAP and 17 (13.1%) viral CAP. LCN2 was higher in bacterial CAP than in non-bacterial CAP (122.0 vs. 89.7 ng/mL, respectively) (p = 0.03) with a limited ability to distinguish bacterial and non-bacterial CAP (AUROC: 0.62 [95% CI 0.52–0.72]). The LCN2 cutoff ≥ 204 ng/mL predicted the presence of pneumococcal bacteremia with an AUROC of 0.74 (sensitivity 70%, specificity 79.1%). Regarding severity, as defined by CURB-65 and PSI scores, there was a significant linear trend in the mean concentration of LCN2, exhibiting a shift from the low-risk to the intermediate-risk and high-risk group (p < 0.001 and 0.001, respectively). LCN2 concentration was associated with severity in adult patients with CAP. However, its utility as a biomarker to discriminate viral and bacterial etiology in CAP is limited. | en |
dc.format.extent | 12 | ca |
dc.language.iso | eng | ca |
dc.publisher | MDPI | ca |
dc.relation.ispartof | Microorganisms | ca |
dc.relation.ispartofseries | 11 | |
dc.relation.uri | https://www.mdpi.com/2076-2607/11/5/1160 | ca |
dc.rights | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Lipocalina-2 | ca |
dc.subject.other | Gravetat | ca |
dc.subject.other | Biomarcador | ca |
dc.subject.other | Pneumònia pneumocòcica | ca |
dc.subject.other | Lipocalina-2 | es |
dc.subject.other | Gravedad | es |
dc.subject.other | Biomarcador | es |
dc.subject.other | Neumonía neumocócica | es |
dc.subject.other | Lipocalin-2 | en |
dc.subject.other | Severity | en |
dc.subject.other | Biomarker | en |
dc.subject.other | Pneumococcal pneumonia | en |
dc.title | Evaluation of plasma lipocalin-2 as a predictor of etiology and severity in adult patients with community-acquired pneumonia | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 61 | ca |
dc.identifier.doi | https://dx.doi.org/10.3390/microorganisms11051160 | ca |
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