Evaluation of plasma lipocalin-2 as a predictor of etiology and severity in adult patients with community-acquired pneumonia
Autor/a
Boix-Palop, Lucía
Vergara, Andrea
Padilla, Emma
Martínez, Diego
Blanco, Ana
Pérez, Josefa
Casals-Pascual, Climent
Data de publicació
2023ISSN
2076-2607
Resum
The aim of this study was to evaluate the diagnostic performance of plasma Lipocalin-2 (LCN2) concentration in adult patients with community-acquired pneumonia (CAP) to determine its etiology, severity and prognosis. A prospective observational study involving adults with CAP from November 2015 to May 2017 was conducted. Plasma LCN2 concentration was measured upon admission by a modified enzyme immunoassay coupled with chemiluminescence (Architect, Abbott Laboratories). The diagnostic performance of LCN2, C-reactive protein (CRP) and white blood cell to predict bacterial CAP was assessed. A total of 130 patients with CAP were included: 71 (54.6%) bacterial CAP, 42 (32.3%) unknown origin CAP and 17 (13.1%) viral CAP. LCN2 was higher in bacterial CAP than in non-bacterial CAP (122.0 vs. 89.7 ng/mL, respectively) (p = 0.03) with a limited ability to distinguish bacterial and non-bacterial CAP (AUROC: 0.62 [95% CI 0.52–0.72]). The LCN2 cutoff ≥ 204 ng/mL predicted the presence of pneumococcal bacteremia with an AUROC of 0.74 (sensitivity 70%, specificity 79.1%). Regarding severity, as defined by CURB-65 and PSI scores, there was a significant linear trend in the mean concentration of LCN2, exhibiting a shift from the low-risk to the intermediate-risk and high-risk group (p < 0.001 and 0.001, respectively). LCN2 concentration was associated with severity in adult patients with CAP. However, its utility as a biomarker to discriminate viral and bacterial etiology in CAP is limited.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
61 - Medicina
Paraules clau
Lipocalina-2
Gravetat
Biomarcador
Pneumònia pneumocòcica
Lipocalina-2
Gravedad
Biomarcador
Neumonía neumocócica
Lipocalin-2
Severity
Biomarker
Pneumococcal pneumonia
Pàgines
12
Publicat per
MDPI
Col·lecció
11
Publicat a
Microorganisms
Citació
Boix-Palop, Lucía; Vergara, Andrea; Padilla, Emma [et al.]. Evaluation of plasma lipocalin-2 as a predictor of etiology and severity in adult patients with community-acquired pneumonia. Microorganisms, 2023, 11(5), 1160. Disponible en: <https://www.mdpi.com/2076-2607/11/5/1160>. Fecha de acceso: 21 jun. 2023. DOI: 10.3390/microorganisms11051160
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Drets
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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