Effects and safety of hypertonic saline combined with airway clearance in non-hospitalized children with recurrent wheezing
Autor/a
González Bellido, Vanesa
Veláz Baza, Verónica
Rama Suárez, Noelia
Jimeno Esteo, Carmen
Sirvent Gomez, Josep
Cuenca Zaldívar, Juan Nicolás
Mayorales lises, Sari
Fagundes Donadio, Márcio Vinícius
Fecha de publicación
2023ISSN
1013-7025
Resumen
Background: The International Study of Wheezing in Infants defines recurrent wheezing as the presence of three or more medically documented episodes of wheezing within one year. To date, there is no evidence on the use of hypertonic saline (HS) combined with airway clearance techniques (ACT) for children with recurrent wheezing treated in an outpatient setting. Therefore, this is the first study to explore the use of such interventions in infants with recurrent wheezing. Objectives: To evaluate the effects and safety of a three-month protocol including HS and ACT for non-hospitalized infants with recurrent wheezing. Methods: Randomized, double-blind, controlled trial, including outpatient infants with recurrent wheezing. Children were randomized to either 3% HS or 0.9% saline groups and were treated with bronchodilator and nebulized with the respective solutions before ACT. The primary outcome was the Wang score. Secondary outcomes included the number of hospitalizations and respiratory crisis, need for rescue medication, and school absences. All variables were measured during the three previous months from inclusion and during intervention period. The study protocol was registered at ClinicalTrials.gov (NCT04331496) on March, 31, 2020. Results: Forty children were included. Regarding immediate effects, significant differences (p<0.001) were found for time, but not for group or interaction (group × time), in all outcome variables (increase in SpO2, decrease in heart and respiratory rate, wheezing episodes, retraction, and Wang score). Comparing the previous three months with the study period, there were significant differences in both groups for the severity of crisis (p<0.001) and medication steps (p=0.002). Conclusion: A three-month protocol including HS and ACT for outpatient infants with recurrent wheezing was safe and reduced morbidity. No differences were found between the use of HS and 0.9% saline.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
61 - Medicina
616.2 - Patología del aparato respiratorio
Palabras clave
Sibilàncies recurrents
Espiració lenta prolongada
Solució salina hipertònica
Neteja de les vies respiratòries
Sibilancias recurrentes
Espiración lenta prolongada
Solución salina hipertónica
Limpieza de las vías respiratorias
Recurrent wheezing
Prolonged slow expiration
Hypertonic saline
Airway clearance
Páginas
11
Publicado por
World Scientific Publishing
Colección
43; 2
Publicado en
Hong Kong Physiotherapy Journal
Citación
González Bellido, Vanesa; Veláz Baza, Verónica; Rama Suárez, Noelia [et al.]. Effects and safety of hypertonic saline combined with airway clearance in non-hospitalized children with recurrent wheezing. Hong Kong Physiotherapy Journal, 2023, 43(2), p. 1-11. Disponible en: <https://www.worldscientific.com/doi/10.1142/S1013702523500105>. Fecha de acceso: 8 may. 2023. DOI: 10.1142/S1013702523500105
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