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Association between soluble angiotensin-converting enzyme 2 in saliva and SARS-CoV-2 infection: a cross-sectional study
dc.contributor.author | Bru, Samuel | |
dc.contributor.author | Brotons, Pedro | |
dc.contributor.author | Jordan, Iolanda | |
dc.contributor.author | Alsina, Laia | |
dc.contributor.author | Henares, Desiree | |
dc.contributor.author | Carballar, Reyes | |
dc.contributor.author | Fernandez de Sevilla, Mariona | |
dc.contributor.author | Barrabeig, Irene | |
dc.contributor.author | Fumado, Victoria | |
dc.contributor.author | Baro, Bàrbara | |
dc.contributor.author | Martínez-Láinez, Joan Marc | |
dc.contributor.author | Garcia-Garcia, Juan J. | |
dc.contributor.author | Bassat, Quique | |
dc.contributor.author | Balaguer, Albert | |
dc.contributor.author | Clotet, Josep | |
dc.contributor.author | Launes, Cristian | |
dc.contributor.author | Muñoz Almagro, Carmen | |
dc.date.accessioned | 2023-04-20T14:15:14Z | |
dc.date.available | 2023-04-20T14:15:14Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Bru, Samuel; Brotons, Pedro; Jordan, Iolanda [et al.]. Association between soluble angiotensin-converting enzyme 2 in saliva and SARS-CoV-2 infection: a cross-sectional study. Scientific Reports, 2023, 13, 5985. Disponible en: <https://www.nature.com/articles/s41598-023-31911-2>. Fecha de acceso: 20 abr. 2023. DOI: 10.1038/s41598-023-31911-2 | ca |
dc.identifier.issn | 2045-2322 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/3678 | |
dc.description.abstract | This study aimed to investigate the association between saliva soluble angiotensin-converting enzyme 2 (sACE2) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adults. We selected a convenience sample of adults with post-acute SARS-CoV-2 infection and their household children living in quarantined family households of the metropolitan Barcelona region (Spain) during the spring 2020 pandemic national lockdown. Participants were tested for saliva sACE2 quantification by western blot and nasopharyngeal SARS-CoV-2 RT-PCR detection. A total of 161 saliva samples [82 (50.9%) from children; 79 (49.1%) from females] yielded valid western blot and RT-PCR results. Saliva sACE2 was detected in 79 (96.3%) children and 76 (96.2%) convalescent adults. Twenty (24.4%) children and 20 (25.3%) convalescent adults were positive for SARS-CoV-2 in nasopharynx by RT-PCR. SARS-CoV-2 RT-PCR-negative children had a significantly higher mean proportional level of saliva sACE2 (0.540 × 10–3%) than RT-PCR-positive children (0.192 × 10–3%, p < 0.001) and convalescent adults (0.173 × 10–3%, p < 0.001). In conclusion, children negative for nasopharyngeal SARS-CoV-2 RT-PCR appear to exhibit a higher concentration of saliva sACE2 than SARS-CoV-2 RT-PCR-positive children and convalescent adults. Release of adequate levels of sACE2 in saliva could play a protective role against SARS-CoV-2. | en |
dc.format.extent | 7 | ca |
dc.language.iso | eng | ca |
dc.publisher | Springer Nature | ca |
dc.relation.ispartof | Scientific Reports | ca |
dc.relation.ispartofseries | 13 | |
dc.relation.uri | https://www.nature.com/articles/s41598-023-31911-2 | ca |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Medicina molecular | ca |
dc.subject.other | Infecció viral | ca |
dc.subject.other | Medicina molecular | es |
dc.subject.other | Infección viral | es |
dc.subject.other | Molecular medicine | en |
dc.subject.other | Viral infection | en |
dc.title | Association between soluble angiotensin-converting enzyme 2 in saliva and SARS-CoV-2 infection: a cross-sectional study | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 616.3 | ca |
dc.identifier.doi | https://dx.doi.org/10.1038/s41598-023-31911-2 | ca |
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