Junctional epithelium and hemidesmosomes: tape and rivets for solving the “percutaneous device dilemma” in dental and other permanent implants
Data de publicació
2022-12ISSN
2452-199X
Resum
The percutaneous device dilemma describes etiological factors, centered around the disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant percutaneous device infection. Natural percutaneous organs, in particular their extracellular matrix mediating the “device”/epithelium interface, serve as exquisite examples to inspire longer lasting long-term percutaneous device design. For example, the tooth's imperviousness to infection is mediated by the epithelium directly surrounding it, the junctional epithelium (JE). The hallmark feature of JE is formation of hemidesmosomes, cell/matrix adhesive structures that attach surrounding oral gingiva to the tooth's enamel through a basement membrane. Here, the authors survey the multifaceted functions of the JE, emphasizing the role of the matrix, with a particular focus on hemidesmosomes and their five main components. The authors highlight the known (and unknown) effects dental implant – as a model percutaneous device – placement has on JE regeneration and synthesize this information for application to other percutaneous devices. The authors conclude with a summary of bioengineering strategies aimed at solving the percutaneous device dilemma and invigorating greater collaboration between clinicians, bioengineers, and matrix biologists.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
616.3 - Patologia de l'aparell digestiu. Odontologia
Paraules clau
Dispositiu percutani
Implant percutani
Hemidesmosomes
Epiteli de unió
Superfícies bioinspirades
Dispositivo percutáneo
Implante percutáneo
Hemidesmosomas
Epitelio de unión
Superficies bioinspiradas
Percutaneous device
Percutaneous implant
Hemidesmosomes
Junctional epithelium
Bioinspired surfaces
Pàgines
21
Publicat per
Elsevier
Col·lecció
18
Publicat a
Bioactive Materials
Citació
Fischer, Nicholas G.; Aparicio, Conrado. Junctional epithelium and hemidesmosomes: tape and rivets for solving the “percutaneous device dilemma” in dental and other permanent implants. Bioactive Materials, 2022, 18, p. 178-198. Disponible en: <https://www.sciencedirect.com/science/article/pii/S2452199X22001359>. Fecha de acceso: 19 abr. 2023. DOI: 10.1016/j.bioactmat.2022.03.019
Enllaç al document relacionat
Aquest element apareix en la col·lecció o col·leccions següent(s)
- Odontologia [245]
Drets
Under a Creative Commons license.
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com https://creativecommons.org/licenses/by-nc-nd/4.0/