Junctional epithelium and hemidesmosomes: tape and rivets for solving the “percutaneous device dilemma” in dental and other permanent implants
Fecha de publicación
2022-12ISSN
2452-199X
Resumen
The percutaneous device dilemma describes etiological factors, centered around the disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant percutaneous device infection. Natural percutaneous organs, in particular their extracellular matrix mediating the “device”/epithelium interface, serve as exquisite examples to inspire longer lasting long-term percutaneous device design. For example, the tooth's imperviousness to infection is mediated by the epithelium directly surrounding it, the junctional epithelium (JE). The hallmark feature of JE is formation of hemidesmosomes, cell/matrix adhesive structures that attach surrounding oral gingiva to the tooth's enamel through a basement membrane. Here, the authors survey the multifaceted functions of the JE, emphasizing the role of the matrix, with a particular focus on hemidesmosomes and their five main components. The authors highlight the known (and unknown) effects dental implant – as a model percutaneous device – placement has on JE regeneration and synthesize this information for application to other percutaneous devices. The authors conclude with a summary of bioengineering strategies aimed at solving the percutaneous device dilemma and invigorating greater collaboration between clinicians, bioengineers, and matrix biologists.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
616.3 - Patología del aparato digestivo. Odontología
Palabras clave
Dispositiu percutani
Implant percutani
Hemidesmosomes
Epiteli de unió
Superfícies bioinspirades
Dispositivo percutáneo
Implante percutáneo
Hemidesmosomas
Epitelio de unión
Superficies bioinspiradas
Percutaneous device
Percutaneous implant
Hemidesmosomes
Junctional epithelium
Bioinspired surfaces
Páginas
21
Publicado por
Elsevier
Colección
18
Publicado en
Bioactive Materials
Citación
Fischer, Nicholas G.; Aparicio, Conrado. Junctional epithelium and hemidesmosomes: tape and rivets for solving the “percutaneous device dilemma” in dental and other permanent implants. Bioactive Materials, 2022, 18, p. 178-198. Disponible en: <https://www.sciencedirect.com/science/article/pii/S2452199X22001359>. Fecha de acceso: 19 abr. 2023. DOI: 10.1016/j.bioactmat.2022.03.019
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- Odontologia [248]
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