dc.contributor.author | Merino Gómez, Maria | |
dc.contributor.author | Gil, FJ | |
dc.contributor.author | Perez, Roman | |
dc.contributor.author | Godoy-Gallardo, Maria | |
dc.date.accessioned | 2023-03-27T14:02:16Z | |
dc.date.available | 2023-03-27T14:02:16Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Merino Gómez, Maria; Gil, FJ; Perez, Roman [et al.]. Polydopamine incorporation enhances cell differentiation and antibacterial properties of 3D-printed guanosine-borate hydrogels for functional tissue regeneration. International Journal of Molecular Sciences, 2023, 24(4), 4224. Disponible en: <https://www.mdpi.com/1422-0067/24/4/4224>. Fecha de acceso: 27 mar. 2023. DOI: 10.3390/ijms24044224 | ca |
dc.identifier.issn | 1422-0067 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/3645 | |
dc.description.abstract | Tissue engineering focuses on the development of materials as biosubstitutes that can be used to regenerate, repair, or replace damaged tissues. Alongside this, 3D printing has emerged as a promising technique for producing implants tailored to specific defects, which in turn increased the demand for new inks and bioinks. Especially supramolecular hydrogels based on nucleosides such as guanosine have gained increasing attention due to their biocompatibility, good mechanical characteristics, tunable and reversible properties, and intrinsic self-healing capabilities. However, most existing formulations exhibit insufficient stability, biological activity, or printability. To address these limitations, we incorporated polydopamine (PDA) into guanosine-borate (GB) hydrogels and developed a PGB hydrogel with maximal PDA incorporation and good thixotropic and printability qualities. The resulting PGB hydrogels exhibited a well-defined nanofibrillar network, and we found that PDA incorporation increased the hydrogel’s osteogenic activity while having no negative effect on mammalian cell survival or migration. In contrast, antimicrobial activity was observed against the Gram-positive bacteria Staphylococcus aureus and Staphylococcus epidermidis. Thus, our findings suggest that our PGB hydrogel represents a significantly improved candidate as a 3D-printed scaffold capable of sustaining living cells, which may be further functionalized by incorporating other bioactive molecules for enhanced tissue integration. | en |
dc.format.extent | 25 | ca |
dc.language.iso | eng | ca |
dc.publisher | MDPI | ca |
dc.relation.ispartof | International Journal of Molecular Sciences | ca |
dc.relation.ispartofseries | 24;4 | |
dc.relation.uri | https://www.mdpi.com/1422-0067/24/4/4224 | ca |
dc.rights | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Hidrogels basats en nucleòsids | ca |
dc.subject.other | Guanosina i derivats | ca |
dc.subject.other | Impressió 3D | ca |
dc.subject.other | Polidopamina | ca |
dc.subject.other | Activitat antibacteriana | ca |
dc.subject.other | Hidrogeles a base de nucleósidos | es |
dc.subject.other | Guanosina y derivados | es |
dc.subject.other | Impresión 3D | es |
dc.subject.other | Polidopamina | es |
dc.subject.other | Actividad antibacterial | es |
dc.subject.other | Nucleoside-based hydrogels | en |
dc.subject.other | Guanosine and derivatives | en |
dc.subject.other | 3D printing | en |
dc.subject.other | Polydopamine | en |
dc.subject.other | Antibacterial activity | en |
dc.title | Polydopamine incorporation enhances cell differentiation and antibacterial properties of 3D-printed guanosine-borate hydrogels for functional tissue regeneration | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 616.3 | ca |
dc.identifier.doi | https://dx.doi.org/10.3390/ijms24044224 | ca |