The effect of oral citicoline and docosahexaenoic acid on the visual field of patients with glaucoma: a randomized trial
Author
Antón López, Alfonso
Garcia, Virginia
Muñoz Escudero, Marcos
Gonzales, Karla
Ayala, Eleonora
Sanchez, Estela del Mar
Morilla-Grasa, Antonio
Publication date
2022ISSN
2075-1729
Abstract
The role of nutraceuticals in the treatment of glaucoma remains controversial. The aim of this study was to evaluate the effect of citicoline, vitamin C, and docosahexaenoic acid (DHA) in patients with glaucoma. Methods: This was a prospective, randomized study. Patients with glaucoma were randomized to one of four groups and treated for 3 months with vitamin C, DHA, citicoline, or a combination of DHA and citicoline. We conducted a complete ophthalmic examination and visual fields each month and calculated the slopes of field indices. Changes in visual field indices (VFIs) and their slopes were assessed in each group and compared. Results: Seventy-three persons were included in the study. Mean defect (MD) significantly improved (p = 0.001) from −9.52 ± 4.36 to −7.85 ± 4.36 dB during the study period in persons taking DHA + citicoline. Similarly, the mean VFI significantly improved (p = 0.001) in this group. The only treatment group showing a statistically significant improvement (p = 0.006) in the MD (from −0.1041 ± 0.2471 to 0.1383 ± 0.2544 dB/month) and VFI slope was the group treated with DHA+citicoline. Conclusions: The combination of oral treatment with DHA + citicoline significantly improved VF indices and their slopes in patients with glaucoma after 3 months of treatment.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Glaucoma
Tractament
Nutracèutics
Àcid docosahexaenoic
Citicolina
Vitamina C
Glaucoma
Tratamiento
Nutracéuticos
Ácido docosahexaenoico
Citicolina
Vitamina C
Glaucoma
Treatment
Nutraceuticals
Docosahexaenoic acid
Citicoline
Vitamin C
Pages
11
Publisher
MDPI
Collection
12
Is part of
Life
Citation
Antón López, Alfonso; Garcia, Virginia; Muñoz Escudero, Marcos [et al.]. The effect of oral citicoline and docosahexaenoic acid on the visual field of patients with glaucoma: a randomized trial. Life, 2022, 12(10), 1481. Disponible en: <https://www.mdpi.com/2075-1729/12/10/1481>. Fecha de acceso: 8 nov. 2022. DOI: 10.3390/life12101481
Link to the related item
This item appears in the following Collection(s)
- Ciències de la Salut [745]
Rights
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/