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Nasopharyngeal microbiota profiling of pregnant women with SARS-CoV-2 infection
dc.contributor.author | Crovetto, Francesca | |
dc.contributor.author | Selma-Royo, Marta | |
dc.contributor.author | Crispi, Fàtima | |
dc.contributor.author | Carbonetto, Belén | |
dc.contributor.author | Pascal, Rosalia | |
dc.contributor.author | Larroya, Marta | |
dc.contributor.author | Casas, Irene | |
dc.contributor.author | Tortajada, Marta | |
dc.contributor.author | Escudero, Nuria | |
dc.contributor.author | Muñoz-Almagro, Carmen | |
dc.contributor.author | Gomez-Roig, Maria Dolores | |
dc.contributor.author | González-Torres, Pedro | |
dc.contributor.author | Collado, Maria Carmen | |
dc.contributor.author | Gratacos, Eduard | |
dc.date.accessioned | 2022-10-03T15:16:16Z | |
dc.date.available | 2022-10-03T15:16:16Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Crovetto, Francesca; Selma-Royo, Marta; Crispi, Fàtima [et al.]. Nasopharyngeal microbiota profiling of pregnant women with SARS-CoV-2 infection. Scientific Reports, 2022, 12, 13404. Disponible en: <https://www.nature.com/articles/s41598-022-17542-z>. Fecha de acceso: 3 oct. 2022. DOI: 10.1038/s41598-022-17542-z | ca |
dc.identifier.issn | 2045-2322 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/3421 | |
dc.description.abstract | We aimed to analyze the nasopharyngeal microbiota profiles in pregnant women with and without SARS-CoV-2 infection, considered a vulnerable population during COVID-19 pandemic. Pregnant women were enrolled from a multicenter prospective population-based cohort during the first SARS-CoV-2 wave in Spain (March-June 2020 in Barcelona, Spain) in which the status of SARS-CoV-2 infection was determined by nasopharyngeal RT–PCR and antibodies in peripheral blood. Women were randomly selected for this cross-sectional study on microbiota. DNA was extracted from nasopharyngeal swab samples, and the V3-V4 region of the 16S rRNA of bacteria was amplified using region-specific primers. The differential abundance of taxa was tested, and alpha/beta diversity was evaluated. Among 76 women, 38 were classified as positive and 38 as negative for SARS-CoV-2 infection. All positive women were diagnosed by SARS-CoV-2 IgG and IgM/IgA antibodies, and 14 (37%) also had a positive RT–PCR. The overall composition of the nasopharyngeal microbiota differ in pregnant women with SARS-CoV-2 infection (positive SARS-CoV-2 antibodies), compared to those without the infection (negative SARS-CoV-2 antibodies) (p = 0.001), with a higher relative abundance of the Tenericutes and Bacteroidetes phyla and a higher abundance of the Prevotellaceae family. Infected women presented a different pattern of microbiota profiling due to beta diversity and higher richness (observed ASV < 0.001) and evenness (Shannon index < 0.001) at alpha diversity. These changes were also present in women after acute infection, as revealed by negative RT–PCR but positive SARS-CoV-2 antibodies, suggesting a potential association between SARS-CoV-2 infection and long-lasting shift in the nasopharyngeal microbiota. No significant differences were reported in mild vs. severe cases. This is the first study on nasopharyngeal microbiota during pregnancy. Pregnant women with SARS-CoV-2 infection had a different nasopharyngeal microbiota profile compared to negative cases. | en |
dc.format.extent | 12 | ca |
dc.language.iso | eng | ca |
dc.publisher | Springer Nature | ca |
dc.relation.ispartof | Scientific Reports | ca |
dc.relation.ispartofseries | 12 | |
dc.relation.uri | https://www.nature.com/articles/s41598-022-17542-z | ca |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | COVID-19 | ca |
dc.subject.other | Microbiota nasofaríngia | ca |
dc.subject.other | Dones embarassades | ca |
dc.subject.other | COVID-19 | es |
dc.subject.other | Microbiota nasofaríngea | es |
dc.subject.other | Mujeres embarazadas | es |
dc.subject.other | COVID-19 | en |
dc.subject.other | Nasopharyngeal microbiota | en |
dc.subject.other | Pregnant women | en |
dc.title | Nasopharyngeal microbiota profiling of pregnant women with SARS-CoV-2 infection | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 61 | ca |
dc.subject.udc | 616.9 | ca |
dc.identifier.doi | https://dx.doi.org/10.1038/s41598-022-17542-z | ca |
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