Prenatal stress induces long-lasting effects in lung glucocorticoid receptor gene expression in a sex-dependent manner
Author
Luft, Carolina
Evangelista Campos, Natália
Moraes Vargas, Mauro Henrique
Fagundes Donadio, Márcio Vinícius
Publication date
2019ISSN
1980-6108
Abstract
AIM: Stressful events during pregnancy may influence respiratory system development, resulting in long-term effects in the offspring. However, little is known on its long-lasting effects upon the expression of important genes in the lungs. Thus, we aimed to evaluate the effect of two different prenatal stress paradigms on lung glucocorticoid receptor (GR) expression in adulthood. METHODS: Pregnant BALB/c mice were divided into 3 groups: control (CON), prenatal stress from the second week of pregnancy (PNS1) and prenatal stress on the last week of pregnancy (PNS2). In both groups (PNS1 and PNS2), restraint stress was used. When adults, male and female offspring were submitted to 30 min of restraint stress. Lung gene expression of GR was evaluated. RESULTS: There was a significant increase in GR expression in males (PNS1), under basal conditions. Restraint stress during adulthood significantly reduced GR expression in PNS1 and PNS2 males as compared to controls. No significant differences were found for females. CONCLUSION: Results indicate that prenatal stress from the second week of gestation modulates adult male mice GR expression in the lungs. Thus, fetal exposure to maternal stress from the second week of gestation seems to modulate mechanisms responsible for pulmonary development in a sex-dependent manner.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
616.2 - Pathology of the respiratory system. Complaints of the respiratory organs
Keywords
Estrès prenatal
Pulmó
Receptor de glucocorticoides
Estrés prenatal
Pulmón
Receptor de glucocorticoides
Prenatal stress
Lung
Glucocorticoid receptor
Pages
6
Publisher
Scientia Medica
Is part of
Scientia Medica
Citation
Luft, Carolina; Evangelista Campos, Natália; Moraes Vargas, Mauro Henrique [et al.]. Prenatal stress induces long-lasting effects in lung glucocorticoid receptor gene expression in a sex-dependent manner. Scientia Medica, 2019, 29(1), e33192. Disponible en: <https://revistaseletronicas.pucrs.br/ojs/index.php/scientiamedica/article/view/33192>. Fecha de acceso: 24 mar. 2022. DOI: 10.15448/1980-6108.2019.1.33192
This item appears in the following Collection(s)
- Ciències de la Salut [712]
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