The following license files are associated with this item:

    The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
    Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/