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SIREs: searching for iron-responsive elements
dc.contributor.author | Campillos, Monica | |
dc.contributor.author | Cases, Ildefonso | |
dc.contributor.author | Hentze, Matthias W. | |
dc.contributor.author | Sanchez, Mayka | |
dc.date.accessioned | 2022-01-18T17:20:37Z | |
dc.date.available | 2022-01-18T17:20:37Z | |
dc.date.issued | 2010-07 | |
dc.identifier.citation | Campillos, Monica; Cases, Ildefonso; Hentze, Matthias W. [et al.]. SIREs: searching for iron-responsive elements. Nucleic Acids Research, 2010, 38 (suppl. 2), W360-W367. Disponible en: <https://academic.oup.com/nar/article/38/suppl_2/W360/1104389>. Fecha de acceso: 18 ene. 2022. DOI: 10.1093/nar/gkq371 | ca |
dc.identifier.issn | 0305-1048 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/3078 | |
dc.description.abstract | The iron regulatory protein/iron-responsive element regulatory system plays a crucial role in the post-transcriptional regulation of gene expression and its disruption results in human disease. IREs are cis-acting regulatory motifs present in mRNAs that encode proteins involved in iron metabolism. They function as binding sites for two related trans-acting factors, namely the IRP-1 and -2. Among cis-acting RNA regulatory elements, the IRE is one of the best characterized. It is defined by a combination of RNA sequence and structure. However, currently available programs to predict IREs do not show a satisfactory level of sensitivity and fail to detect some of the functional IREs. Here, we report an improved software for the prediction of IREs implemented as a user-friendly web server tool. The SIREs web server uses a simple data input interface and provides structure analysis, predicted RNA folds, folding energy data and an overall quality flag based on properties of well characterized IREs. Results are reported in a tabular format and as a schematic visual representation that highlights important features of the IRE. | en |
dc.format.extent | 8 | ca |
dc.language.iso | eng | ca |
dc.publisher | Oxford University Press | ca |
dc.relation.ispartof | Nucleic Acids Research | ca |
dc.relation.ispartofseries | 38;2 | |
dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/2.5 | |
dc.subject.other | Proteïna reguladora del ferro | ca |
dc.subject.other | Ferro | ca |
dc.subject.other | Expressió gènica | ca |
dc.subject.other | ARNm | ca |
dc.subject.other | Metabolisme del ferro | ca |
dc.subject.other | Proteína reguladora del hierro | es |
dc.subject.other | Hierro | es |
dc.subject.other | Expresión génica | es |
dc.subject.other | ARNm | es |
dc.subject.other | Metabolismo del hierro | es |
dc.subject.other | Iron-regulating protein | en |
dc.subject.other | Iron | en |
dc.subject.other | Gene expression | en |
dc.subject.other | MRNA | en |
dc.subject.other | Iron metabolism | en |
dc.title | SIREs: searching for iron-responsive elements | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 57 | ca |
dc.identifier.doi | https://dx.doi.org/10.1093/nar/gkq371 | ca |
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