SIREs: searching for iron-responsive elements
Visualitza/Obre
Autor/a
Campillos, Monica
Cases, Ildefonso
Hentze, Matthias W.
Sanchez, Mayka
Data de publicació
2010-07ISSN
0305-1048
Resum
The iron regulatory protein/iron-responsive element regulatory system plays a crucial role in the post-transcriptional regulation of gene expression and its disruption results in human disease. IREs are cis-acting regulatory motifs present in mRNAs that encode proteins involved in iron metabolism. They function as binding sites for two related trans-acting factors, namely the IRP-1 and -2. Among cis-acting RNA regulatory elements, the IRE is one of the best characterized. It is defined by a combination of RNA sequence and structure. However, currently available programs to predict IREs do not show a satisfactory level of sensitivity and fail to detect some of the functional IREs. Here, we report an improved software for the prediction of IREs implemented as a user-friendly web server tool. The SIREs web server uses a simple data input interface and provides structure analysis, predicted RNA folds, folding energy data and an overall quality flag based on properties of well characterized IREs. Results are reported in a tabular format and as a schematic visual representation that highlights important features of the IRE.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
57 - Biologia
Paraules clau
Proteïna reguladora del ferro
Ferro
Expressió gènica
ARNm
Metabolisme del ferro
Proteína reguladora del hierro
Hierro
Expresión génica
ARNm
Metabolismo del hierro
Iron-regulating protein
Iron
Gene expression
MRNA
Iron metabolism
Pàgines
8
Publicat per
Oxford University Press
Col·lecció
38; 2
Publicat a
Nucleic Acids Research
Citació
Campillos, Monica; Cases, Ildefonso; Hentze, Matthias W. [et al.]. SIREs: searching for iron-responsive elements. Nucleic Acids Research, 2010, 38 (suppl. 2), W360-W367. Disponible en: <https://academic.oup.com/nar/article/38/suppl_2/W360/1104389>. Fecha de acceso: 18 ene. 2022. DOI: 10.1093/nar/gkq371
Aquest element apareix en la col·lecció o col·leccions següent(s)
- Ciències de la Salut [740]
Drets
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com http://creativecommons.org/licenses/by-nc/2.5