ATP, Mg2+, nuclear phase separation, and genome accessibility
Autor/a
Wright, Roni
Le Dily, François
Beato, Miguel
Fecha de publicación
2019ISSN
0968-0004
Resumen
Misregulation of the processes controlling eukaryotic gene expression can result in disease. Gene expression is influenced by the surrounding chromatin; hence the nuclear environment is also of vital importance. Recently, understanding of chromatin hierarchical folding has increased together with the discovery of membrane-less organelles which are distinct, dynamic liquid droplets that merge and expand within the nucleus. These ‘sieve’-like regions may compartmentalize and separate functionally distinct regions of chromatin. This article aims to discuss recent studies on nuclear phase within the context of poly(ADP-ribose), ATP, and Mg2+ levels, and we propose a combinatorial complex role for these molecules in phase separation and genome regulation. We also discuss the implications of this process for gene regulation and discuss possible strategies to test this.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
54 - Química
Palabras clave
Dinàmica de la cromatina
Topologia del genoma 3D
Separació de fases
Orgànuls sense membrana
Regulació gènica
Magnesi
Dinámica de la cromatina
Topología del genoma 3D
Separación de fases
Orgánulos sin membrana
Regulación génica
Magnesio
Chromatin dynamics
3D genome topology
Phase separation
Organelles without membrane
Gene regulation
Magnesium
Páginas
10
Publicado por
Elsevier
Colección
44; 7
Publicado en
Trends in Biochemical Sciences
Citación
Wright, Roni H.G.; Le Dily, Francois; Beato, Miguel. ATP, Mg2+, nuclear phase separation, and genome accessibility. Trends in Biochemical Sciences, 2019, 44(7), p. 565-574. Disponible en: <https://www.sciencedirect.com/science/article/pii/S0968000419300532>. Fecha de acceso: 14 dic. 2021. DOI: 10.1016/j.tibs.2019.03.001
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Derechos
© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Excepto si se señala otra cosa, la licencia del ítem se describe como https://creativecommons.org/licenses/by-nc-nd/4.0/