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dc.contributor.authorWright, Roni
dc.contributor.authorLe Dily, François
dc.contributor.authorBeato, Miguel
dc.date.accessioned2021-12-14T17:31:37Z
dc.date.available2021-12-14T17:31:37Z
dc.date.issued2019
dc.identifier.citationWright, Roni H.G.; Le Dily, Francois; Beato, Miguel. ATP, Mg2+, nuclear phase separation, and genome accessibility. Trends in Biochemical Sciences, 2019, 44(7), p. 565-574. Disponible en: <https://www.sciencedirect.com/science/article/pii/S0968000419300532>. Fecha de acceso: 14 dic. 2021. DOI: 10.1016/j.tibs.2019.03.001ca
dc.identifier.issn0968-0004ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/3020
dc.description.abstractMisregulation of the processes controlling eukaryotic gene expression can result in disease. Gene expression is influenced by the surrounding chromatin; hence the nuclear environment is also of vital importance. Recently, understanding of chromatin hierarchical folding has increased together with the discovery of membrane-less organelles which are distinct, dynamic liquid droplets that merge and expand within the nucleus. These ‘sieve’-like regions may compartmentalize and separate functionally distinct regions of chromatin. This article aims to discuss recent studies on nuclear phase within the context of poly(ADP-ribose), ATP, and Mg2+ levels, and we propose a combinatorial complex role for these molecules in phase separation and genome regulation. We also discuss the implications of this process for gene regulation and discuss possible strategies to test this.en
dc.format.extent10ca
dc.language.isoengca
dc.publisherElsevierca
dc.relation.ispartofTrends in Biochemical Sciencesca
dc.relation.ispartofseries44;7
dc.rights© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.otherDinàmica de la cromatinaca
dc.subject.otherTopologia del genoma 3Dca
dc.subject.otherSeparació de fasesca
dc.subject.otherOrgànuls sense membranaca
dc.subject.otherRegulació gènicaca
dc.subject.otherMagnesica
dc.subject.otherDinámica de la cromatinaes
dc.subject.otherTopología del genoma 3Des
dc.subject.otherSeparación de faseses
dc.subject.otherOrgánulos sin membranaes
dc.subject.otherRegulación génicaes
dc.subject.otherMagnesioes
dc.subject.otherChromatin dynamicsen
dc.subject.other3D genome topologyen
dc.subject.otherPhase separationen
dc.subject.otherOrganelles without membraneen
dc.subject.otherGene regulationen
dc.subject.otherMagnesiumen
dc.titleATP, Mg2+, nuclear phase separation, and genome accessibilityen
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc54ca
dc.identifier.doihttps://dx.doi.org/10.1016/j.tibs.2019.03.001ca


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© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/
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