dc.contributor.author | Wright, Roni | |
dc.contributor.author | Le Dily, François | |
dc.contributor.author | Beato, Miguel | |
dc.date.accessioned | 2021-12-14T17:31:37Z | |
dc.date.available | 2021-12-14T17:31:37Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Wright, Roni H.G.; Le Dily, Francois; Beato, Miguel. ATP, Mg2+, nuclear phase separation, and genome accessibility. Trends in Biochemical Sciences, 2019, 44(7), p. 565-574. Disponible en: <https://www.sciencedirect.com/science/article/pii/S0968000419300532>. Fecha de acceso: 14 dic. 2021. DOI: 10.1016/j.tibs.2019.03.001 | ca |
dc.identifier.issn | 0968-0004 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/3020 | |
dc.description.abstract | Misregulation of the processes controlling eukaryotic gene expression can result in disease. Gene expression is influenced by the surrounding chromatin; hence the nuclear environment is also of vital importance. Recently, understanding of chromatin hierarchical folding has increased together with the discovery of membrane-less organelles which are distinct, dynamic liquid droplets that merge and expand within the nucleus. These ‘sieve’-like regions may compartmentalize and separate functionally distinct regions of chromatin. This article aims to discuss recent studies on nuclear phase within the context of poly(ADP-ribose), ATP, and Mg2+ levels, and we propose a combinatorial complex role for these molecules in phase separation and genome regulation. We also discuss the implications of this process for gene regulation and discuss possible strategies to test this. | en |
dc.format.extent | 10 | ca |
dc.language.iso | eng | ca |
dc.publisher | Elsevier | ca |
dc.relation.ispartof | Trends in Biochemical Sciences | ca |
dc.relation.ispartofseries | 44;7 | |
dc.rights | © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.other | Dinàmica de la cromatina | ca |
dc.subject.other | Topologia del genoma 3D | ca |
dc.subject.other | Separació de fases | ca |
dc.subject.other | Orgànuls sense membrana | ca |
dc.subject.other | Regulació gènica | ca |
dc.subject.other | Magnesi | ca |
dc.subject.other | Dinámica de la cromatina | es |
dc.subject.other | Topología del genoma 3D | es |
dc.subject.other | Separación de fases | es |
dc.subject.other | Orgánulos sin membrana | es |
dc.subject.other | Regulación génica | es |
dc.subject.other | Magnesio | es |
dc.subject.other | Chromatin dynamics | en |
dc.subject.other | 3D genome topology | en |
dc.subject.other | Phase separation | en |
dc.subject.other | Organelles without membrane | en |
dc.subject.other | Gene regulation | en |
dc.subject.other | Magnesium | en |
dc.title | ATP, Mg2+, nuclear phase separation, and genome accessibility | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 54 | ca |
dc.identifier.doi | https://dx.doi.org/10.1016/j.tibs.2019.03.001 | ca |