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LoxTnSeq: random transposon insertions combined with cre/lox recombination and counterselection to generate large random genome reductions
(John Wiley & Sons, 2021)
The removal of unwanted genetic material is a key aspect in many synthetic biology efforts and often requires preliminary knowledge of which genomic regions are dispensable. Typically, these efforts are ...
The ADP-ribose hydrolase NUDT5 is important for DNA repair
(Springer Nature, 2022-12)
DNA damage leads to rapid synthesis of poly(ADP-ribose) (pADPr), which is important for damage signaling and repair. pADPr chains are removed by poly(ADP-ribose) glycohydrolase (PARG), releasing free ...
Simplified qualitative discrete numerical model to determine cracking pattern in brittle materials by means of finite element method
(Hindawi, 2017)
This paper presents the formulation, implementation, and validation of a simplified qualitative model to determine the crack path of solids considering static loads, infinitesimal strain, and plane ...
Regulation of actin dynamics during structural plasticity of dendritic spines: signaling messengers and actin-binding proteins
(Elsevier, 2018-09)
Activity-dependent plasticity of synaptic structure and function plays an essential role in neuronal development and in cognitive functions including learning and memory. The formation, maintenance and ...
Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation
(Springer Nature, 2019)
Manipulation of neuronal activity using two-photon excitation of azobenzene photoswitches with near-infrared light has been recently demonstrated, but their practical use in neuronal tissue to photostimulate ...
Unliganded progesterone receptor governs estrogen receptor gene expression by regulating DNA methylation in breast cancer cells
(MDPI, 2018)
Breast cancer prognosis and response to endocrine therapy strongly depends on the expression of the estrogen and progesterone receptors (ER and PR, respectively). Although much is known about ERα gene ...
Influence of bone-level dental implants placement and of cortical thickness on osseointegration: in silico and in vivo analyses
(MDPI, 2022)
The purpose of this research is to study the biomechanical response of dental implants in bone-level type locations, 0.5 mm above and below the bone level. In addition, the influence of the thickness ...
Improved dynamical particle swarm optimization method for structural dynamics
(Hindawi, 2019)
A methodology to the multiobjective structural design of buildings based on an improved particle swarm optimization algorithm is presented, which has proved to be very efficient and robust in nonlinear ...
Effectiveness of a multicomponent training program on physical performance and muscle quality in older adults: a quasi-experimental study
(MDPI, 2023)
Aging is associated with a decrease in functional capacity, manifested by a loss of strength, physical performance and muscle quality. Multicomponent training (MCT), characterized by the combination of ...
Iron Regulation and the Cell Cycle: identification of an iron-responsive element in the 3′-untranslated region of human cell division cycle 14a mrna by a refined microarray-based screening strategy
(Elsevier, 2006)
Iron regulatory proteins (IRPs) 1 and 2 post-transcriptionally control mammalian iron homeostasis by binding to iron-responsive elements (IREs), conserved RNA stem-loop structures located in the 5′- or ...