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dc.contributor.authorBrotons, Pedro
dc.contributor.authorLaunes, Cristian
dc.contributor.authorBuetas, Elena
dc.contributor.authorFumado, Vicky
dc.contributor.authorHenares, Desirée
dc.contributor.authorFernandez de Sevilla, Mariona
dc.contributor.authorRedin, Alba
dc.contributor.authorFuente-Soro, Laura
dc.contributor.authorCuadras, Daniel
dc.contributor.authorMele, Maria
dc.contributor.authorJou, Cristina
dc.contributor.authorMillat, Pere
dc.contributor.authorJordan, Iolanda
dc.contributor.authorGarcia-Garcia, Juan Jose
dc.contributor.authorBassat, Quique
dc.contributor.authorMuñoz-Almagro, Carmen
dc.contributor.authorKids Corona Study Group
dc.date.accessioned2021-07-13T17:51:05Z
dc.date.available2021-07-13T17:51:05Z
dc.date.issued2021-06
dc.identifier.citationBrotons, Pedro; Launes, Cristian; Buetas, Elena [et al.]. Susceptibility to severe acute respiratory syndrome coronavirus 2 infection among children and adults: a seroprevalence study of family households in the Barcelona metropolitan region, Spain. Clinical Infectious Diseases, 2021, 72(12), e970-977. Disponible en: <https://academic.oup.com/cid/article/72/12/e970/5979490>. Fecha de acceso: 13 jul. 2021. DOI: 10.1093/cid/ciaa1721ca
dc.identifier.issn1058-4838ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/2687
dc.description.abstractBackground: Susceptibility of children and adults to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and persistence of antibody response to the virus after infection resolution remain poorly understood, despite their significant public health implications. Methods: A prospective cross-sectional seroprevalence study with volunteer families that included at least 1 first-reported adult case positive by SARS-CoV-2 by polymerase chain reaction (PCR) and at least 1 child aged <15 years living in the same household under strict home confinement was conducted in the metropolitan Barcelona Health Region, Spain, during the pandemic period 28 April 2020–3 June 2020. All household members were tested at home using a rapid SARS-CoV-2 antibody assay with finger prick–obtained capillary blood. Results: A total of 381 family households including 381 first-reported PCR-positive adult cases and 1084 contacts (672 children, 412 adults) were enrolled. SARS-CoV-2 seroprevalence rates were 17.6% (118 of 672) in children and 18.7% (77 of 335) in adult contacts (P = .64). Among first-reported cases, seropositivity rates varied from 84.0% in adults previously hospitalized and tested within 6 weeks since the first positive PCR result to 31.5% in those not hospitalized and tested after that lag time (P < .001). Nearly all (99.9%) positive children were asymptomatic or had mild symptoms. Conclusions: Children appear to have similar probability as adults to become infected by SARS-CoV-2 in quarantined family households but remain largely asymptomatic. Adult antibody protection against SARS-CoV-2 seems to be weak beyond 6 weeks post-infection confirmation, especially in cases that have experienced mild disease.en
dc.format.extent8ca
dc.language.isoengca
dc.publisherOxford University Pressca
dc.relation.ispartofClinical Infectious Diseasesca
dc.relation.ispartofseries72;12
dc.rights© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.comen
dc.subject.otherCOVID-19 (malaltia)ca
dc.subject.otherFormació d’anticossosca
dc.subject.otherSíndrome respiratòria agudaca
dc.subject.otherPandèmiesca
dc.subject.otherSeroprevalènciaca
dc.subject.otherCOVID-19es
dc.subject.otherFormación de anticuerposes
dc.subject.otherSíndrome respiratorio agudoes
dc.subject.otherPandemiases
dc.subject.otherSeroprevalenciaes
dc.subject.otherCOVID-19en
dc.subject.otherFormació d’anticossosen
dc.subject.otherSíndrome respiratòria agudaen
dc.subject.otherPandèmiesen
dc.subject.otherSeroprevalènciaen
dc.titleSusceptibility to severe acute respiratory syndrome coronavirus 2 infection among children and adults: a seroprevalence study of family households in the Barcelona metropolitan region, Spainen
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc61ca
dc.subject.udc616.9ca
dc.identifier.doihttps://dx.doi.org/10.1093/cid/ciaa1721ca


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