dc.contributor.author | Díez-Tercero, Leire | |
dc.contributor.author | Delgado, Luis M. | |
dc.contributor.author | Bosch-Rué, Elia | |
dc.contributor.author | Pérez Antoñanzas, Roman | |
dc.date.accessioned | 2021-06-21T15:30:16Z | |
dc.date.available | 2021-06-21T15:30:16Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Díez-Tercero, Leire; Delgado, Luis M.; Bosch-Rué, Elia [et al.]. Evaluation of the immunomodulatory effects of cobalt, copper and magnesium ions in a pro inflammatory environment. Scientific Reports, 2021, 11, 11707. Disponible en: <https://www.nature.com/articles/s41598-021-91070-0>. Fecha de acceso: 21 jun. 2021. DOI: 10.1038/s41598-021-91070-0 | ca |
dc.identifier.issn | 2045-2322 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/2643 | |
dc.description.abstract | Biomaterials and scaffolds for Tissue Engineering are widely used for an effective healing and regeneration. However, the implantation of these scaffolds causes an innate immune response in which the macrophage polarization from M1 (pro-inflammatory) to M2 (anti-inflammatory) phenotype is crucial to avoid chronic inflammation. Recent studies have showed that the use of bioactive ions such as cobalt (Co2+), copper (Cu2+) and magnesium (Mg2+) could improve tissue regeneration, although there is limited evidence on their effect on the macrophage response. Therefore, we investigated the immunomodulatory potential of Co2+, Cu2+ and Mg2+ in macrophage polarization. Our results indicate that Mg2+ and concentrations of Cu2+ lower than 10 μM promoted the expression of M2 related genes. However, higher concentrations of Cu2+ and Co2+ (100 μM) stimulated pro-inflammatory marker expression, indicating a concentration dependent effect of these ions. Furthermore, Mg2+ were able to decrease M1 marker expression in presence of a mild pro-inflammatory stimulus, showing that Mg2+ can be used to modulate the inflammatory response, even though their application can be limited in a strong pro-inflammatory environment. | en |
dc.format.extent | 13 | ca |
dc.language.iso | eng | ca |
dc.publisher | Springer Nature | ca |
dc.relation.ispartof | Scientific Reports | ca |
dc.relation.ispartofseries | 11; | |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Enginyeria biomèdica | ca |
dc.subject.other | Biomedicina | ca |
dc.subject.other | Inflamació | ca |
dc.subject.other | Biomaterials | ca |
dc.subject.other | Enginyeria de teixits | ca |
dc.subject.other | Resposta immune | ca |
dc.subject.other | Inflamació crònica | ca |
dc.subject.other | Ingeniería biomédica | es |
dc.subject.other | Biomedicina | es |
dc.subject.other | Inflamación | es |
dc.subject.other | Biomateriales | es |
dc.subject.other | Ingeniería de tejidos | es |
dc.subject.other | Respuesta inmune | es |
dc.subject.other | Inflamación crónica | es |
dc.subject.other | Biomedical engineering | en |
dc.subject.other | Biomedicine | en |
dc.subject.other | Inflammation | en |
dc.subject.other | Biomaterials | en |
dc.subject.other | Tissue engineering | en |
dc.subject.other | Immune response | en |
dc.subject.other | Chronic inflammation | en |
dc.title | Evaluation of the immunomodulatory effects of cobalt, copper and magnesium ions in a pro inflammatory environment | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2PE/RTI2018-096088-J-100 | ca |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2PE/RYC2018-025977-I | ca |
dc.subject.udc | 61 | ca |
dc.subject.udc | 62 | ca |
dc.identifier.doi | https://dx.doi.org/10.1038/s41598-021-91070-0 | ca |