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Prevalence of hepatitis E infection in HIV/HCV-coinfected patients in Spain (2012–2014)
dc.contributor.author | Vázquez-Morón, Sonia | |
dc.contributor.author | Berenguer, Juan | |
dc.contributor.author | González-García, Juan | |
dc.contributor.author | Jiménez-Sousa, Maria Ángeles | |
dc.contributor.author | Canorea, Isabel | |
dc.contributor.author | Guardiola Tey, Josep Maria | |
dc.contributor.author | Crespo, Manuel | |
dc.contributor.author | Quereda, Carmen | |
dc.contributor.author | Sanz, José | |
dc.contributor.author | Carrero, Ana | |
dc.contributor.author | Hontañón, Víctor | |
dc.contributor.author | Avellón, Ana | |
dc.contributor.author | Resino, Salvador | |
dc.date.accessioned | 2021-06-17T17:00:29Z | |
dc.date.available | 2021-06-17T17:00:29Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Vázquez-Morón, Sonia; Berenguer, Juan; González-García, Juan [et al]. Prevalence of hepatitis E infection in HIV/HCV-coinfected patients in Spain (2012–2014). Scientific Reports, 2019, 9, 1143. Disponible en: <https://www.nature.com/articles/s41598-018-37328-6A. Fecha de acceso: 17 jun. 2021. DOI: 10.1038/s41598-018-37328-6 | ca |
dc.identifier.issn | 2045-2322 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/2637 | |
dc.description.abstract | Hepatitis E virus (HEV) has emerged as a relevant pathogen for HIV-infected patients. However, there is scarce data on HEV infection in HIV/HCV-coinfected individuals with advanced fibrosis, which seems to increase the risk of HEV infection and worsen the prognosis of liver disease. We aimed to determine the prevalence of anti-HEV antibodies, acute hepatitis E, resolved hepatitis E, and exposure to HEV in HIV/HCV-coinfected patients and to evaluate associations with clinical and epidemiological characteristics. We performed a cross-sectional study on 198 HIV/HCV-coinfected patients, 30 healthy controls and 36 HIV-monoinfected patients. We found a low concordance between techniques used for detection of anti-HEV antibodies (ELISA versus Immunoblot), particularly in HIV/HCV-coinfected patients. HIV/HCV-coinfected patients showed the highest prevalence of IgG against HEV, resolved hepatitis E, and exposure to HEV (19.2%, 17.2%, and 22.2% respectively). However, we did not find any samples positive for HEV-RNA nor significant differences between groups. Moreover, HIV/HCV-coinfected patients with CD4 T-cells <350 cells/mm3 had higher prevalence for anti-HEV IgG antibodies, resolved hepatitis E, and exposure to HEV than healthy controls or those with CD4 T-cells ≥ 350 cells/mm3 (p = 0.034, p = 0.035, and p = 0.053; respectively). In conclusion, HIV/HCV-coinfected patients in Spain have a high prevalence for IgG anti-HEV antibodies, resolved hepatitis E, and exposure to HEV; particularly patients with CD4+T-cells <350 cells/mm3. | en |
dc.format.extent | 7 | ca |
dc.language.iso | eng | ca |
dc.publisher | Springer Nature | ca |
dc.relation.ispartof | Scientific Reports | ca |
dc.relation.ispartofseries | 9; | |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Diagnòstic de malalties infeccioses | ca |
dc.subject.other | Epidemiologia vírica | ca |
dc.subject.other | Hepatitis E | ca |
dc.subject.other | VIH / VHC | ca |
dc.subject.other | Diagnóstico de enfermedades infecciosas | es |
dc.subject.other | Epidemiología vírica | es |
dc.subject.other | Hepatitis E | es |
dc.subject.other | VIH / VHC | es |
dc.subject.other | Diagnosis of infectious diseases | en |
dc.subject.other | Viral epidemiology | en |
dc.subject.other | Hepatitis E | en |
dc.subject.other | HIV / HCV | en |
dc.title | Prevalence of hepatitis E infection in HIV/HCV-coinfected patients in Spain (2012–2014) | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 61 | ca |
dc.subject.udc | 616.9 | ca |
dc.identifier.doi | https://dx.doi.org/10.1038/s41598-018-37328-6 | ca |
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