Eradication of hepatitis C virus and non-liver-related non–acquired immune deficiency syndrome–related events in human immunodeficiency virus/hepatitis C virus coinfection
Author
Berenguer, Juan
Rodríguez-Castellano, Elena
Carrero, Ana
Von Wichmann, Miguel A.
Montero, Marta
Galindo, María J.
Mallolas, Josep
Crespo, Manuel
Téllez, María J.
Quereda, Carmen
Sanz, José
Barros, Carlos
Tural, Cristina
Santos, Ignacio
Pulido, Federico
Guardiola Tey, Josep Maria
Rubio, Rafael
Ortega, Enrique
Montes, María L.
Jusdado, Juan J.
Gaspar, Gabriel
Esteban, Herminia
Bellón, José M.
González-García, Juan
GESIDA HIV-HCV Cohort Study Group
Publication date
2017ISSN
1527-3350
Abstract
We assessed non-liver-related non–acquired immunodeficiency syndrome (AIDS)-related (NLR-NAR) events and mortalityin a cohort of human immunodeficiency virus (HIV)/hepatitis C virus (HCV)–coinfected patients treated with interferon(IFN) and ribavirin (RBV), between 2000 and 2008. The censoring date was May 31, 2014. Cox regression analysis was per-formed to assess the adjusted hazard rate (HR) of overall death in responders and nonresponders. Fine and Gray regressionanalysis was conducted to determine the adjusted subhazard rate (sHR) of NLR deaths and NLR-NAR events consideringdeath as the competing risk. The NLR-NAR events analyzed included diabetes mellitus, chronic renal failure, cardiovascularevents, NLR-NAR cancer, bone events, and non-AIDS-related infections. The variables for adjustment were age, sex, pastAIDS, HIV transmission category, nadir CD41T-cell count, antiretroviral therapy, HIV RNA, liver fibrosis, HCV genotype,and exposure to specific anti-HIV drugs. Of the 1,625 patients included, 592 (36%) had a sustained viral response (SVR). Aftera median 5-year follow-up, SVR was found to be associated with a significant decrease in the hazard of diabetes mellitus (sHR,0.57; 95% confidence interval [CI], 0.35-0.93; P 5 0.024) and decline in the hazard of chronic renal failure close to the thresh-old of significance (sHR, 0.43; 95% CI, 0.17-1.09; P 5 0.075). Conclusion: Our data suggest that eradication of HCV in coin-fected patients is associated not only with a reduction in the frequency of death, HIV progression, and liver-related events, butalso with a reduced hazard of diabetes mellitus and possibly of chronic renal failure. These findings argue for the prescription ofHCV therapy in coinfected patients regardless of fibrosis stage.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
616.9 - Communicable diseases. Infectious and contagious diseases, fevers
Keywords
Síndrome d’immunodeficiència no adquirida
SIDA
Fetge
Mortalitat
Virus de la Immunodeficiència Humana
VIH
Hepatitis C
VHC
Síndrome de inmunodeficiencia no adquirida
SIDA
Hígado
Mortalidad
Virus de la Inmunodeficiencia Humana
VIH
Hepatitis C
VHC
Non–acquired immunodeficiency syndrome
SIDA
Liver
Mortality
Human Immunodeficiency Virus
VIH
Hepatitis C
VHC
Pages
13
Publisher
John Wiley & Sons, Inc.
Collection
66; 2
Is part of
Hepatology
Citation
Berenguer, Juan; Rodríguez-Castellano, Elena; Carrero, Ana [et al.]. Eradication of hepatitis C virus and non-liver-related non–acquired immune deficiency syndrome–related events in human immunodeficiency virus/hepatitis C virus coinfection. Hepatology, 2017, 66(2), p. 344-356. Disponible en: <https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.29071>. Fecha de acceso: 14 jun. 2021. DOI: 10.1002/hep.29071
This item appears in the following Collection(s)
- Ciències de la Salut [745]
Rights
© 2017 The Authors. Hepatology published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc/4.0/