dc.contributor.author | Rubio-Rivas, Manuel | |
dc.contributor.author | Corbella Virós, Xavier | |
dc.contributor.author | Formiga, Francesc | |
dc.contributor.author | Menéndez Fernández, Estela | |
dc.contributor.author | Martín Escalante, María Dolores | |
dc.contributor.author | Baños Fernández, Isolina | |
dc.contributor.author | Arnalich Fernández, Francisco | |
dc.contributor.author | Del Corral-Beamonte, Esther | |
dc.contributor.author | Lalueza, Antonio | |
dc.contributor.author | Parra Virto, Alejandro | |
dc.contributor.author | Roy Vallejo, Emilia | |
dc.contributor.author | Loureiro-Amigo, José | |
dc.contributor.author | Álvarez Suárez, Ana María | |
dc.contributor.author | Abadía-Otero, Jesica | |
dc.contributor.author | Navarro De La Chica, María | |
dc.contributor.author | Estévez González, Raquel | |
dc.contributor.author | Hernández Milián, Almudena | |
dc.contributor.author | Areses Manrique, María | |
dc.contributor.author | Blázquez Encinar, Julio César | |
dc.contributor.author | González Noya, Amara | |
dc.contributor.author | González Ferrer, Ruth | |
dc.contributor.author | Pérez Aguilera, María | |
dc.contributor.author | Gil Sánchez, Ricardo | |
dc.contributor.author | Millán Núñez-Cortés, Jesús | |
dc.contributor.author | Casas-Rojo, José Manuel | |
dc.contributor.author | SEMI-COVID-19 Network | |
dc.date.accessioned | 2021-06-07T14:58:44Z | |
dc.date.available | 2021-06-07T14:58:44Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Rubio-Rivas, Manuel; Corbella Virós, Xavier; Formiga, Francesc [et al.]. Risk categories in COVID-19 based on degrees of inflammation: data on more than 17,000 patients from the spanish SEMI-COVID-19 registry. Journal of Clinical Medicine, 2021, 10(10), 2214. Disponible en: <https://www.mdpi.com/2077-0383/10/10/2214>. Fecha de acceso: 7 jun. 2021. DOI: 10.3390/jcm10102214 | ca |
dc.identifier.issn | 2077-0383 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/2603 | |
dc.description.abstract | (1) Background: The inflammation or cytokine storm that accompanies COVID-19 marks the prognosis. This study aimed to identify three risk categories based on inflammatory parameters on admission. (2) Methods: Retrospective cohort study of patients diagnosed with COVID-19, collected and followed-up from 1 March to 31 July 2020, from the nationwide Spanish SEMI-COVID-19 Registry. The three categories of low, intermediate, and high risk were determined by taking into consideration the terciles of the total lymphocyte count and the values of C-reactive protein, lactate dehydrogenase, ferritin, and D-dimer taken at the time of admission. (3) Results: A total of 17,122 patients were included in the study. The high-risk group was older (57.9 vs. 64.2 vs. 70.4 years; p < 0.001) and predominantly male (37.5% vs. 46.9% vs. 60.1%; p < 0.001). They had a higher degree of dependence in daily tasks prior to admission (moderate-severe dependency in 10.8% vs. 14.1% vs. 17%; p < 0.001), arterial hypertension (36.9% vs. 45.2% vs. 52.8%; p < 0.001), dyslipidemia (28.4% vs. 37% vs. 40.6%; p < 0.001), diabetes mellitus (11.9% vs. 17.1% vs. 20.5%; p < 0.001), ischemic heart disease (3.7% vs. 6.5% vs. 8.4%; p < 0.001), heart failure (3.4% vs. 5.2% vs. 7.6%; p < 0.001), liver disease (1.1% vs. 3% vs. 3.9%; p = 0.002), chronic renal failure (2.3% vs. 3.6% vs. 6.7%; p < 0.001), cancer (6.5% vs. 7.2% vs. 11.1%; p < 0.001), and chronic obstructive pulmonary disease (5.7% vs. 5.4% vs. 7.1%; p < 0.001). They presented more frequently with fever, dyspnea, and vomiting. These patients more frequently required high flow nasal cannula (3.1% vs. 4.4% vs. 9.7%; p < 0.001), non-invasive mechanical ventilation (0.9% vs. 3% vs. 6.3%; p < 0.001), invasive mechanical ventilation (0.6% vs. 2.7% vs. 8.7%; p < 0.001), and ICU admission (0.9% vs. 3.6% vs. 10.6%; p < 0.001), and had a higher percentage of in-hospital mortality (2.3% vs. 6.2% vs. 23.9%; p < 0.001). The three risk categories proved to be an independent risk factor in multivariate analyses. (4) Conclusion: The present study identifies three risk categories for the requirement of high flow nasal cannula, mechanical ventilation, ICU admission, and in-hospital mortality based on lymphopenia and inflammatory parameters. | en |
dc.format.extent | 13 | ca |
dc.language.iso | eng | ca |
dc.publisher | MDPI | ca |
dc.relation.ispartof | Journal of Clinical Medicine | ca |
dc.relation.ispartofseries | 10; | |
dc.rights | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | COVID-19 (Malaltia) | ca |
dc.subject.other | Tempesta de citoquines | ca |
dc.subject.other | Pronòstic | |
dc.subject.other | Factors de risc | |
dc.subject.other | Mortalitat | |
dc.subject.other | COVID-19 | es |
dc.subject.other | Tormenta de citoquinas | es |
dc.subject.other | Pronóstico | es |
dc.subject.other | Factores de riesgo | es |
dc.subject.other | Mortalidad | es |
dc.subject.other | COVID-19 | en |
dc.subject.other | Cytokine storm | en |
dc.subject.other | Prognosis | en |
dc.subject.other | Risk factors | en |
dc.subject.other | Mortality | en |
dc.title | Risk categories in COVID-19 based on degrees of inflammation: data on more than 17,000 patients from the spanish SEMI-COVID-19 registry | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 61 | ca |
dc.subject.udc | 616.9 | ca |
dc.identifier.doi | https://dx.doi.org/10.3390/jcm10102214 | ca |