Biofabrication of tissue engineering vascular systems
Author
Zhang, Qiao
Bosch-Rué, Elia
Pérez Antoñanzas, Roman
Truskey, George A.
Publication date
2021-05ISSN
2473-2877
Abstract
Cardiovascular disease (CVD) is the leading cause of death among persons aged 65 and older in the United States and many other developed countries. Tissue engineered vascular systems (TEVS) can serve as grafts for CVD treatment and be used as in vitro model systems to examine the role of various genetic factors during the CVD progressions. Current focus in the field is to fabricate TEVS that more closely resembles the mechanical properties and extracellular matrix environment of native vessels, which depends heavily on the advance in biofabrication techniques and discovery of novel biomaterials. In this review, we outline the mechanical and biological design requirements of TEVS and explore the history and recent advances in biofabrication methods and biomaterials for tissue engineered blood vessels and microvascular systems with special focus on in vitro applications. In vitro applications of TEVS for disease modeling are discussed.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medicina
616.1 - Patologia del sistema circulatori, dels vasos sanguinis. Trastorns cardiovasculars
Keywords
Enginyeria de teixits
Sistema cardiovascular -- Malalties
Materials biomèdics
Ingeniería de tejidos
Aparato circulatorio -- Enfermedades
Materiales biomédicos
Tissue engineering
Cardiovascular system -- Diseases
Biomedical materials
Pages
19
Publisher
AIP Publishing LLC
Collection
5;2
Is part of
APL Bioengineering
Citation
Zhang, Qiao; Bosch-Rué, Èlia; Pérez, Román A. Biofabrication of tissue engineering vascular systems. APL Bioengineering, 2021, 5(2), 021507. Disponible en: <https://aip.scitation.org/doi/10.1063/5.0039628>. Fecha de acceso: 28 may. 2021. DOI: 10.1063/5.0039628
Grant agreement number
info:eu-repo/grantAgreement/ES/2PE/RYC2018-025977-I
info:eu-repo/grantAgreement/ES/2PE/RTI2018–096088-J-10
This item appears in the following Collection(s)
- Ciències de la Salut [532]
Rights
© 2021 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/