Biofabrication of tissue engineering vascularsystems
Pérez, Román A.
Truskey, George A.
Cardiovascular disease (CVD) is the leading cause of death among persons aged 65 and older in the United States and many other developed countries. Tissue engineered vascular systems (TEVS) can serve as grafts for CVD treatment and be used as in vitro model systems to examine the role of various genetic factors during the CVD progressions. Current focus in the field is to fabricate TEVS that more closely resembles the mechanical properties and extracellular matrix environment of native vessels, which depends heavily on the advance in biofabrication techniques and discovery of novel biomaterials. In this review, we outline the mechanical and biological design requirements of TEVS and explore the history and recent advances in biofabrication methods and biomaterials for tissue engineered blood vessels and microvascular systems with special focus on in vitro applications. In vitro applications of TEVS for disease modeling are discussed.
61 - Medicina
616.1 - Patologia del sistema circulatori, dels vasos sanguinis. Trastorns cardiovasculars
Enginyeria de teixits
Sistema cardiovascular -- Malalties
Ingeniería de tejidos
Aparato circulatorio -- Enfermedades
Cardiovascular system -- Diseases
AIP Publishing LLC
Is part of
Zhang, Qiao; Bosch-Rué, Èlia; Pérez, Román A. Biofabrication of tissue engineering vascularsystems. APL Bioengineering, 2021, 5(2), 021507. Disponible en: <https://aip.scitation.org/doi/10.1063/5.0039628>. Fecha de acceso: 28 may. 2021. DOI: 10.1063/5.0039628
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- Ciències de la Salut 
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