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dc.contributor.authorFernández-Cidón, Bárbara
dc.contributor.authorCandás-Estébanez, Beatriz
dc.contributor.authorGil-Serret, Miriam
dc.contributor.authorAmigó, Núria
dc.contributor.authorCorbella, Emili
dc.contributor.authorRodríguez-Sánchez, M. Ángeles
dc.contributor.authorPadró-Miquel, Ariadna
dc.contributor.authorBrotons, Carlos
dc.contributor.authorHernández-Mijares, Antonio
dc.contributor.authorCalmarza, Pilar
dc.contributor.authorJarauta, Estibaliz
dc.contributor.authorBrea, Angel J.
dc.contributor.authorMauri, Marta
dc.contributor.authorGuijarro, Carlos
dc.contributor.authorVila, Àlex
dc.contributor.authorValdivielso, Pedro
dc.contributor.authorCorbella Virós, Xavier
dc.contributor.authorPintó, Xavier
dc.date.accessioned2021-05-18T15:19:02Z
dc.date.available2021-05-18T15:19:02Z
dc.date.issued2021
dc.identifier.citationFernández-Cidón, Bárbara; Candás-Estébanez, Beatriz; Gil-Serret, Miriam [et al.]. Physicochemical properties of lipoproteins assessed by nuclear magnetic resonance as a predictor of premature cardiovascular disease. PRESARV-SEA study. Journal of Clinical Medicine, 2021, 10(7), 1379. Disponible en: <https://www.mdpi.com/2077-0383/10/7/1379>. Fecha de acceso: 18 may. 2021. DOI: 10.3390/jcm10071379ca
dc.identifier.issn2077-0383ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/2550
dc.description.abstractSome lipoprotein disorders related to the residual risk of premature cardiovascular disease (PCVD) are not detected by the conventional lipid profile. In this case-control study, the predictive power of PCVD of serum sdLDL-C, measured using a lipoprotein precipitation method, and of the physicochemical properties of serum lipoproteins, analyzed by nuclear magnetic resonance (NMR) techniques, were evaluated. We studied a group of patients with a first PCVD event (n = 125) and a group of control subjects (n = 190). Conventional lipid profile, the size and number of Very Low Density Lipoproteins (VLDL), Low Density Lipoproteins (LDL), High Density Lipoproteins (HDL) particles, and the number of particles of their subclasses (large, medium, and small) were measured. Compared to controls, PCVD patients had lower concentrations of all LDL particles, and smaller and larger diameter of LDL and HDL particles, respectively. PCVD patients also showed higher concentrations of small dense LDL-cholesterol (sdLDL), and triglycerides (Tg) in LDL and HDL particles (HDL-Tg), and higher concentrations of large VLDL particles. Multivariate logistic regression showed that sdLDL-C, HDL-Tg, and large concentrations of LDL particles were the most powerful predictors of PCVD. A strong relationship was observed between increased HDL-Tg concentrations and PCVD. This study demonstrates that beyond the conventional lipid profile, PCVD patients have other atherogenic lipoprotein alterations that are detected by magnetic resonance imaging (MRI) analysis.en
dc.format.extent10ca
dc.language.isoengca
dc.publisherMDPIca
dc.relation.ispartofJournal of Clinical Medicineca
dc.relation.ispartofseries10;7
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.otherCor -- Malaltiesca
dc.subject.otherCirculació coronàriaca
dc.subject.otherLipoproteïnesca
dc.subject.otherLípidsca
dc.subject.otherArteriosclerosica
dc.subject.otherInfart de miocardica
dc.subject.otherMiocardi -- Revascularitzacióca
dc.subject.otherCorazón -- Enfermedadeses
dc.subject.otherCirculación coronariaes
dc.subject.otherLipoproteínases
dc.subject.otherLípidoses
dc.subject.otherArteriosclerosises
dc.subject.otherInfarto de miocardioes
dc.subject.otherRevascularización miocárdicaes
dc.subject.otherHeart -- Diseasesen
dc.subject.otherCoronary circulationen
dc.subject.otherLipoproteinsen
dc.subject.otherLipidsen
dc.subject.otherArteriosclerosisen
dc.subject.otherMyocardial infarctionen
dc.subject.otherMyocardium -- Revascularizationen
dc.titlePhysicochemical properties of lipoproteins assessed by nuclear magnetic resonance as a predictor of premature cardiovascular disease. PRESARV-SEA studyen
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc61ca
dc.subject.udc616.1ca
dc.identifier.doihttps://dx.doi.org/10.3390/jcm10071379ca


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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/