Show simple item record

dc.contributor.authorFraioli, Roberta
dc.contributor.authorRechenmacher, Florian
dc.contributor.authorNeubauer, Stefanie
dc.contributor.authorManero Planella, José M.
dc.contributor.authorFrancisco Javier, Gil Mur
dc.contributor.authorKessler, Horst
dc.contributor.authorMas Moruno, Carlos
dc.date.accessioned2021-05-10T17:31:02Z
dc.date.available2021-05-10T17:31:02Z
dc.date.issued2015-04-01
dc.identifier.citationFraioli, Roberta; Rechenmacher, Florian; Neubauer, Stefanie [et al.]. Mimicking bone extracellular matrix: integrin-binding peptidomimetics enhance osteoblast-like cells adhesion, proliferation, and differentiation on titanium. Colloids and Surfaces B: Biointerfaces, 2015, 128, p. 191-200. Disponible en: <https://www.sciencedirect.com/science/article/pii/S0927776515000168?via%3Dihub>. Fecha de acceso: 10 may. 2021. DOI: 10.1016/j.colsurfb.2014.12.057ca
dc.identifier.issn0927-7765ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/2532
dc.description.abstractInteraction between the surface of implants and biological tissues is a key aspect of biomaterials research. Apart from fulfilling the non-toxicity and structural requirements, synthetic materials are asked to direct cell response, offering engineered cues that provide specific instructions to cells. This work explores the functionalization of titanium with integrin-binding peptidomimetics as a novel and powerful strategy to improve the adhesion, proliferation and differentiation of osteoblast-like cells to implant materials. Such biomimetic strategy aims at targeting integrins αvβ3 and α5β1, which are highly expressed on osteoblasts and are essential for many fundamental functions in bone tissue development. The successful grafting of the bioactive molecules on titanium is proven by contact angle measurements, X-ray photoelectron spectroscopy and fluorescent labeling. Early attachment and spreading of cells are statistically enhanced by both peptidomimetics compared to unmodified titanium, reaching values of cell adhesion comparable to those obtained with full-length extracellular matrix proteins. Moreover, an increase in alkaline phosphatase activity, and statistically higher cell proliferation and mineralization are observed on surfaces coated with the peptidomimetics. This study shows an unprecedented biological activity for low-molecular-weight ligands on titanium, and gives striking evidence of the potential of these molecules to foster bone regeneration on implant materials.en
dc.format.extent10ca
dc.language.isoengca
dc.publisherElsevierca
dc.relation.ispartofColloids and Surfaces B: Biointerfacesca
dc.relation.ispartofseries128;
dc.rightsUnder a Creative Commons licenseen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.otherOsteointegracióca
dc.subject.otherMaterials biomèdicsca
dc.subject.otherOssos -- Regeneracióca
dc.subject.otherOsteointegraciónes
dc.subject.otherMateriales biomédicoses
dc.subject.otherHuesos -- Regeneraciónes
dc.subject.otherOsteointegrationen
dc.subject.otherBiomedical materialsen
dc.subject.otherBones -- Regenerationen
dc.titleMimicking bone extracellular matrix: integrin-binding peptidomimetics enhance osteoblast-like cells adhesion, proliferation, and differentiation on titaniumen
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/321985ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/6PN/MAT2012-30706ca
dc.subject.udc57ca
dc.subject.udc61ca
dc.identifier.doihttps://dx.doi.org/10.1016/j.colsurfb.2014.12.057ca


Files in this item

 

This item appears in the following Collection(s)

Show simple item record

Under a Creative Commons license
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/