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Pneumococcal serotypes in children, clinical presentation and antimicrobial susceptibility in the PCV13 era
dc.contributor.author | Izquierdo, Conchita | |
dc.contributor.author | Ciruela, Pilar | |
dc.contributor.author | Hernández, Sergi | |
dc.contributor.author | García-García, Juan José | |
dc.contributor.author | Esteva, Cristina | |
dc.contributor.author | Moraga-Llop, Fernando | |
dc.contributor.author | Díaz-Conradi, A. | |
dc.contributor.author | Martínez-Osorio, Johanna | |
dc.contributor.author | Solé-Ribalta, Anna | |
dc.contributor.author | De Sevilla, Mariona F. | |
dc.contributor.author | González-Peris, Sebastià | |
dc.contributor.author | Codina, Gemma | |
dc.contributor.author | Planes, Ana María | |
dc.contributor.author | Uriona, Sonia | |
dc.contributor.author | Campins, Magda | |
dc.contributor.author | Muñoz-Almagro, Carmen | |
dc.contributor.author | Salleras, Luis | |
dc.contributor.author | Domínguez, Ángela | |
dc.date.accessioned | 2021-02-12T13:26:37Z | |
dc.date.available | 2021-02-12T13:26:37Z | |
dc.date.issued | 2020-11 | |
dc.identifier.citation | Izquierdo, C.; Ciruela, P.; Hernández, S. [et al.]. Pneumococcal serotypes in children, clinical presentation and antimicrobial susceptibility in the PCV13 era. Epidemiology and Infection, 2020, 148, e279. Disponible en: <https://www.cambridge.org/core/journals/epidemiology-and-infection/article/pneumococcal-serotypes-in-children-clinical-presentation-and-antimicrobial-susceptibility-in-the-pcv13-era/AE1B808500024D32F81D250C12155339#>. Fecha de acceso: 12 feb. 2021. DOI: 10.1017/ S0950268820002708 | ca |
dc.identifier.issn | 0950-2688 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/1991 | |
dc.description.abstract | The aim was to analyse invasive pneumococcal disease (IPD) serotypes in children aged ⩽17 years according to clinical presentation and antimicrobial susceptibility. We conducted a prospective study (January 2012–June 2016). IPD cases were diagnosed by culture and/or real-time polymerase chain reaction (PCR). Demographic, microbiological and clinical data were analysed. Associations were assessed using the odds ratio (OR) and 95% confidence intervals (CI). Of the 253 cases, 34.4% were aged <2 years, 38.7% 2–4 years and 26.9% 5–17 years. Over 64% were 13-valent pneumococcal conjugate vaccine (PCV13) serotypes. 48% of the cases were diagnosed only by real-time PCR. Serotypes 3 and 1 were associated with complicated pneumonia (P < 0.05) and non-PCV13 serotypes with meningitis (OR 7.32, 95% CI 2.33–22.99) and occult bacteraemia (OR 3.6, 95% CI 1.56–8.76). Serotype 19A was more frequent in children aged <2 years and serotypes 3 and 1 in children aged 2–4 years and 5–17 years, respectively. 36.1% of cases were not susceptible to penicillin and 16.4% were also non-susceptible to cefotaxime. Serotypes 14, 24F and 23B were associated with non-susceptibility to penicillin (P < 0.05) and serotypes 11, 14 and 19A to cefotaxime (P < 0.05). Serotype 19A showed resistance to penicillin (P = 0.002). In conclusion, PCV13 serotypes were most frequent in children aged ⩽17 years, mainly serotypes 3, 1 and 19A. Non-PCV13 serotypes were associated with meningitis and occult bacteraemia and PCV13 serotypes with pneumonia. Non-susceptibility to antibiotics of non-PCV13 serotypes should be monitored. | ca |
dc.format.extent | 12 | ca |
dc.language.iso | eng | ca |
dc.publisher | Cambridge University Press | ca |
dc.relation.ispartof | Epidemiology and Infection | ca |
dc.relation.ispartofseries | 148; | |
dc.rights | © The Author(s), 2020. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Infants -- Salut i higiene | ca |
dc.subject.other | Pneumococs | ca |
dc.subject.other | Vacunes | ca |
dc.subject.other | Penicil·lina | ca |
dc.subject.other | Niños -- Salud e Higiene | es |
dc.subject.other | Streptococcus pneumoniae | es |
dc.subject.other | Vacunas | es |
dc.subject.other | Penicilina | es |
dc.subject.other | Children -- Health and hygiene | en |
dc.subject.other | Pneumococcus | en |
dc.subject.other | Vaccines | en |
dc.subject.other | Penicillin | en |
dc.title | Pneumococcal serotypes in children, clinical presentation and antimicrobial susceptibility in the PCV13 era | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 61 | ca |
dc.identifier.doi | https://doi.org/10.1017/ S0950268820002708 | ca |
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