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dc.contributor.authorCerdà, Pau
dc.contributor.authorRibas, Jesús
dc.contributor.authorIriarte, Adriana
dc.contributor.authorMora-Luján, José María
dc.contributor.authorTorres, Raquel
dc.contributor.authorDel Río, Belén
dc.contributor.authorJofre, Héctor Ignacio
dc.contributor.authorRuiz, Yolanda
dc.contributor.authorHuguet, Marta
dc.contributor.authorFuset, Mari Paz
dc.contributor.authorMartínez-Yélamos, Sergio
dc.contributor.authorSantos, Salud
dc.contributor.authorLlecha, Núria
dc.contributor.authorCorbella Virós, Xavier
dc.contributor.authorRiera-Mestre, Antoni
dc.date.accessioned2021-02-04T08:57:45Z
dc.date.available2021-02-04T08:57:45Z
dc.date.issued2020-12-28
dc.identifier.citationCerdà, Pau; Ribas, Jesus; Iriarte, Adriana [et al.]. Blood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosis. PLoS One, 2020, 15(12), e0243533. Disponible en: <https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0243533>. Fecha de acceso: 2 feb. 2021. DOI: 10.1371/journal.pone.0243533ca
dc.identifier.issn1932-6203ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/1971
dc.description.abstractBackground: A higher incidence of thrombotic events, mainly pulmonary embolism (PE), has been reported in hospitalized patients with COVID-19. The main objective was to assess clinical and laboratory differences in hospitalized COVID-19 patients according to occurrence of PE. Methods: This retrospective study included all consecutive patients hospitalized with COVID-19 who underwent a computed tomography (CT) angiography for PE clinical suspicion. Clinical data and median blood test results distributed into weekly periods from COVID-19 symptoms onset, were compared between PE and non-PE patients. Results: Ninety-two patients were included, 29 (32%) had PE. PE patients were younger (63.9 (SD 13.7) vs 69.9 (SD 12.5) years). Clinical symptoms and COVID-19 CT features were similar in both groups. PE was diagnosed after a mean of 20.0 (SD 8.6) days from the onset of COVID-19 symptoms. Corticosteroid boluses were more frequently used in PE patients (62% vs. 43%). No patients met ISTH DIC criteria. Any parameter was statistically significant or clinically relevant except for D-Dimer when comparing both groups. Median values [IQR] of D-dimer in PE vs non-PE patients were: week 2 (2010.7 [770.1–11208.9] vs 626.0 [374.0–2382.2]; p = 0.004); week 3 (3893.1 [1388.2–6694.0] vs 1184.4 [461.8–2447.8]; p = 0.003); and week 4 (2736.3 [1202.1–8514.1] vs 1129.1 [542.5–2834.6]; p = 0.01). Median fold-increase of D-dimer between week 1 and 2 differed between groups (6.64 [3.02–23.05] vs 1.57 [0.64–2.71], p = 0.003); ROC curve AUC was 0.879 (p = 0.003) with a sensitivity and specificity for PE of 86% and 80%, respectively. Conclusions: Among hospitalized COVID-19 patients, D-dimer levels are higher at weeks 2, 3 and 4 after COVID-19 symptom onset in patients who develop PE. This difference is more pronounced when the fold increase between weeks 1 and 2 is compared.ca
dc.format.extent15ca
dc.language.isoengca
dc.publisherPublic Library of Scienceca
dc.relation.ispartofPLoS Oneca
dc.relation.ispartofseries15;12
dc.rights©2020 Cerdà et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ca
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.otherEmbòlia pulmonarca
dc.subject.otherHospitals--Pacientsca
dc.subject.otherCOVID-19 (Malaltia)ca
dc.subject.otherCorticosteroidesca
dc.subject.otherEmbolia pulmonarca
dc.subject.otherHospitalizadosca
dc.subject.otherCOVID-19ca
dc.subject.otherCorticosteroidesca
dc.subject.otherPulmonary embolismca
dc.subject.otherHospitals--Patientsca
dc.subject.otherCOVID-19ca
dc.subject.otherCorticosteroidsca
dc.titleBlood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosisca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc61ca
dc.identifier.doihttps://dx.doi.org/10.1371/journal.pone.0243533ca


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©2020 Cerdà et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/
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