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dc.contributor.authorMir, Joan Francesc
dc.contributor.authorZagmutt, Sebastián
dc.contributor.authorLichtenstein, Mathieu P.
dc.contributor.authorGarcía-Villoria, Judit
dc.contributor.authorWeber, Minéia
dc.contributor.authorGracia, Ana
dc.contributor.authorFabriàs, Gemma
dc.contributor.authorCasas, Josefina
dc.contributor.authorLópez, Miguel
dc.contributor.authorCasals i Farré, Núria
dc.contributor.authorRibes, Antònia
dc.contributor.authorSuñol, Cristina
dc.contributor.authorHerrero Rodríguez, Laura
dc.contributor.authorSerra, Dolors
dc.date.accessioned2020-06-18T18:30:41Z
dc.date.available2020-06-18T18:30:41Z
dc.date.issued2018
dc.identifier.citationMir, Joan Francesc; Zagmutt, Sebastián; Lichtenstein, Mathieu P. [et al.]. Ghrelin causes a decline in GABA release by reducing fatty acid oxidation in cortex. Molecular Neurobiology, 2018, 55, p. 7216-7228. Disponible en: <https://link.springer.com/article/10.1007/s12035-018-0921-3>. Fecha de acceso: 18 jun. 2020. DOI: 10.1007/s12035-018-0921-3.ca
dc.identifier.issn1559-1182ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/1589
dc.description.abstractLipid metabolism, specifically fatty acid oxidation (FAO) mediated by carnitine palmitoyltransferase (CPT) 1A, has been described to be an important actor of ghrelin action in hypothalamus. However, it is not known whether CPT1A and FAO mediate the effect of ghrelin on the cortex. Here, we show that ghrelin produces a differential effect on CPT1 activity and γ-aminobutyric acid (GABA) metabolism in the hypothalamus and cortex of mice. In the hypothalamus, ghrelin enhances CPT1A activity while GABA transaminase (GABAT) activity, a key enzyme in GABA shunt metabolism, is unaltered. However, in cortex CPT1A activity and GABAT activity are reduced after ghrelin treatment. Furthermore, in primary cortical neurons, ghrelin reduces GABA release through a CPT1A reduction. By using CPT1A floxed mice, we have observed that genetic ablation of CPT1A recapitulates the effect of ghrelin on GABA release in cortical neurons, inducing reductions in mitochondrial oxygen consumption, cell content of citrate and α-ketoglutarate, and GABA shunt enzyme activity. Taken together, these observations indicate that ghrelin-induced changes in CPT1A activity modulate mitochondrial function, yielding changes in GABA metabolism. This evidence suggests that the action of ghrelin on GABA release is region specific within the brain, providing a basis for differential effects of ghrelin in the central nervous system.ca
dc.format.extent13ca
dc.language.isoengca
dc.publisherMolecular Neurobiologyca
dc.relation.ispartofSpringer Natureca
dc.relation.ispartofseries55;
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.ca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.otherÀcids grassosca
dc.subject.otherNeurones
dc.subject.otherHormones
dc.subject.otherSomatotropina
dc.subject.otherHipotàlem
dc.subject.otherÁcidos grasos
dc.subject.otherNeuronas
dc.subject.otherHormonas
dc.subject.otherSomatotropina
dc.subject.otherHipotálamo
dc.subject.otherFatty acids
dc.subject.otherNeurons
dc.subject.otherHormones
dc.subject.otherSomatotropin
dc.subject.otherHypothalamus
dc.titleGhrelin causes a decline in GABA release by reducing fatty acid oxidation in cortexca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/acceptedVersionca
dc.embargo.termscapca
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/ICTI2013-2016/SAF2015-71026-Rca
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/ICTI2013-2016/BFU2015-70454-REDTca
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/ICTI2013-2016/SAF2013-45887-Rca
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/ICTI2013-2016/SAF2014-52223-C2-1-Rca
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/ICTI2013-2016/SAF2014-52223-C2-2-Rca
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/281854ca
dc.subject.udc61ca
dc.identifier.doihttps://dx.doi.org/10.1007/s12035-018-0921-3ca


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This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
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