Antibacterial properties of triethoxysilylpropyl succinic anhydride silane (TESPSA) on titanium dental implants
Autor/a
Buxadera-Palomero, Judit
Godoy-Gallardo, Maria
Gil Mur, Francisco Javier
Fecha de publicación
2020ISSN
2073-4360
Resumen
Infections related to dental implants are a common complication that can ultimately lead to implant failure, and thereby carries significant health and economic costs. In order to ward off these infections, this paper explores the immobilization of triethoxysilylpropyl succinic anhydride (TESPSA, TSP) silane onto dental implants, and the interaction of two distinct monospecies biofilms and an oral plaque with the coated titanium samples. To this end, titanium disks from prior machining were first activated by a NaOH treatment and further functionalized with TESPSA silane. A porous sodium titanate surface was observed by scanning electron microscopy and X-ray photoelectron spectroscopy analyses confirmed the presence of TESPSA on the titanium samples (8.4% for Ti–N-TSP). Furthermore, a lactate dehydrogenase assay concluded that TESPSA did not have a negative effect on the viability of human fibroblasts. Importantly, the in vitro effect of modified surfaces against Streptococcus sanguinis, Lactobacillus salivarius and oral plaque were studied using a viable bacterial adhesion assay. A significant reduction was achieved in all cases but, as expected, with different effectiveness against simple mono-species biofilm (ratio dead/live of 0.4) and complete oral biofilm (ratio dead/live of 0.6). Nevertheless, this approach holds a great potential to provide dental implants with antimicrobial properties.
Tipo de documento
Artículo
Versión del documento
Versión aceptada
Lengua
English
Materias (CDU)
616.3 - Patología del aparato digestivo. Odontología
Palabras clave
Implants dentals
Titani
Bactericides
Biofilms
Infecció
Lactobacil·làcies
Implantes dentales
Titanio
Bacteriocinas
Biofilms
Infección
Lactobacilos
Dental implants
Titanium
Bactericides
Biofilms
Infection
Lactobacillus
Páginas
15
Publicado por
MDPI
Colección
12; 4
Publicado en
Polymers
Citación
Buxadera-Palomero, Judit; Godoy-Gallardo, Maria; Molmeneu, Meritxell [et al.]. Antibacterial properties of triethoxysilylpropyl succinic anhydride silane (TESPSA) on titanium dental implants. Polymers, 2020, 12(4), p. 1-15. Disponible en: <https://www.mdpi.com/2073-4360/12/4/773>. Fecha de acceso: 20 may. 2020. DOI: 10.3390/polym12040773
Número del acuerdo de la subvención
info:eu-repo/grantAgreement/MICINN/RTI2018-098075-B-C22
Este ítem aparece en la(s) siguiente(s) colección(ones)
- Odontologia [239]
Derechos
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Excepto si se señala otra cosa, la licencia del ítem se describe como https://creativecommons.org/licenses/by/4.0/