Antibacterial properties of triethoxysilylpropyl succinic anhydride silane (TESPSA) on titanium dental implants
Autor/a
Buxadera-Palomero, Judit
Godoy-Gallardo, Maria
Gil Mur, Francisco Javier
Data de publicació
2020ISSN
2073-4360
Resum
Infections related to dental implants are a common complication that can ultimately lead to implant failure, and thereby carries significant health and economic costs. In order to ward off these infections, this paper explores the immobilization of triethoxysilylpropyl succinic anhydride (TESPSA, TSP) silane onto dental implants, and the interaction of two distinct monospecies biofilms and an oral plaque with the coated titanium samples. To this end, titanium disks from prior machining were first activated by a NaOH treatment and further functionalized with TESPSA silane. A porous sodium titanate surface was observed by scanning electron microscopy and X-ray photoelectron spectroscopy analyses confirmed the presence of TESPSA on the titanium samples (8.4% for Ti–N-TSP). Furthermore, a lactate dehydrogenase assay concluded that TESPSA did not have a negative effect on the viability of human fibroblasts. Importantly, the in vitro effect of modified surfaces against Streptococcus sanguinis, Lactobacillus salivarius and oral plaque were studied using a viable bacterial adhesion assay. A significant reduction was achieved in all cases but, as expected, with different effectiveness against simple mono-species biofilm (ratio dead/live of 0.4) and complete oral biofilm (ratio dead/live of 0.6). Nevertheless, this approach holds a great potential to provide dental implants with antimicrobial properties.
Tipus de document
Article
Versió del document
Versió acceptada
Llengua
English
Matèries (CDU)
616.3 - Patologia de l'aparell digestiu. Odontologia
Paraules clau
Implants dentals
Titani
Bactericides
Biofilms
Infecció
Lactobacil·làcies
Implantes dentales
Titanio
Bacteriocinas
Biofilms
Infección
Lactobacilos
Dental implants
Titanium
Bactericides
Biofilms
Infection
Lactobacillus
Pàgines
15
Publicat per
MDPI
Col·lecció
12; 4
Publicat a
Polymers
Citació
Buxadera-Palomero, Judit; Godoy-Gallardo, Maria; Molmeneu, Meritxell [et al.]. Antibacterial properties of triethoxysilylpropyl succinic anhydride silane (TESPSA) on titanium dental implants. Polymers, 2020, 12(4), p. 1-15. Disponible en: <https://www.mdpi.com/2073-4360/12/4/773>. Fecha de acceso: 20 may. 2020. DOI: 10.3390/polym12040773
Número de l'acord de la subvenció
info:eu-repo/grantAgreement/MICINN/RTI2018-098075-B-C22
Aquest element apareix en la col·lecció o col·leccions següent(s)
- Odontologia [239]
Drets
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com https://creativecommons.org/licenses/by/4.0/