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Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
dc.contributor.author | Palomo Guerrero, Marta | |
dc.contributor.author | Fadó Andrés, Rut | |
dc.contributor.author | Casas, Maria | |
dc.contributor.author | Pérez-Montero, Marta | |
dc.contributor.author | Baena, Miguel | |
dc.contributor.author | Helmer, Patrick O. | |
dc.contributor.author | Domínguez, José Luis | |
dc.contributor.author | Roig, Aina | |
dc.contributor.author | Serra, Dolors | |
dc.contributor.author | Hayen, Heiko | |
dc.contributor.author | Stenmark, Harald | |
dc.contributor.author | Raiborg, Camilla | |
dc.contributor.author | Casals i Farré, Núria | |
dc.date.accessioned | 2020-05-27T15:45:22Z | |
dc.date.available | 2020-05-27T15:45:22Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Palomo-Guerrero, Marta; Fadó Andrés, Rut; Casas, Maria [et al.]. Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth. eLife, 2019, 8, e51063. Disponible en: <https://elifesciences.org/articles/51063>. Fecha de acceso: 27 may. 2020. DOI: 10.7554/eLife.51063. | ca |
dc.identifier.issn | 2050-084X | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/1551 | |
dc.description.abstract | Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty acids, and its intracellular levels highly fluctuate depending on glucose availability or the energy sensor AMP-activated protein kinase (AMPK). We demonstrate in HeLa cells that carnitine palmitoyltransferase 1C (CPT1C) senses malonyl-CoA and enhances LE/Lys anterograde transport by interacting with the endoplasmic reticulum protein protrudin and facilitating the transfer of Kinesin-1 from protrudin to LE/Lys. In cultured mouse cortical neurons, glucose deprivation, pharmacological activation of AMPK or inhibition of malonyl-CoA synthesis decreases LE/Lys abundance at the axon terminal, and shortens axon length in a CPT1C-dependent manner. These results identify CPT1C as a new regulator of anterograde LE/Lys transport in response to malonyl-CoA changes, and give insight into how axon growth is controlled by nutrients. | ca |
dc.format.extent | 26 | ca |
dc.language.iso | eng | ca |
dc.publisher | eLife Sciences Publications | ca |
dc.relation.ispartof | eLife | ca |
dc.relation.ispartofseries | 8; | |
dc.rights | © Palomo-Guerrero et. al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. | ca |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Lisosomes | ca |
dc.subject.other | Àcids grassos | |
dc.subject.other | Glucosa | |
dc.subject.other | Neurones | |
dc.subject.other | Axons | |
dc.subject.other | Citologia | |
dc.subject.other | Neurociències | |
dc.subject.other | Ratolins | |
dc.subject.other | Lisosomas | |
dc.subject.other | Ácidos grasos | |
dc.subject.other | Glucosa | |
dc.subject.other | Neuronas | |
dc.subject.other | Axiomas | |
dc.subject.other | Citología | |
dc.subject.other | Neurociencias | |
dc.subject.other | Ratones | |
dc.subject.other | Lysosomes | |
dc.subject.other | Fatty acids | |
dc.subject.other | Glucose | |
dc.subject.other | Neurons | |
dc.subject.other | Axons | |
dc.subject.other | Cytology | |
dc.subject.other | Neurosciences | |
dc.subject.other | Mice | |
dc.title | Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/acceptedVersion | ca |
dc.embargo.terms | cap | ca |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2PE/SAF2017-83813-C3-1-R | ca |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/1PE/SAF2014-52223-C2-2-R | ca |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2PE/SAF2017-82813-C3-3R | ca |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/1PE/SAF2014-52223-C2-1-R | ca |
dc.subject.udc | 61 | ca |
dc.identifier.doi | http://dx.doi.org/10.7554/eLife.51063 | ca |
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