Effects of autologous adipose-derived regenerative stem cells administered at the time of anterior cruciate ligament reconstruction on knee function and graft healing
Author
Alentorn-Geli, Eduard
Seijas, Roberto
Martínez-De la Torre, Adrián
Cuscó, Xavier
Steinbacher, Gilbert
Álvarez Díaz, Pedro
Barastegui, David
Navarro, Jordi
Serra Renom, Josep Maria
Nishishinya, Betina
Català, Jordi
Laiz, Patricia
García-Balletbó, Montserrat
Cugat, Ramón
Publication date
2019ISSN
2309-4990
Abstract
Purpose: To compare the healing and clinical outcomes of anterior cruciate ligament (ACL) reconstruction between patients with or without intraoperative administration of adipose-derived regenerative stem cells (ADRC). Methods: Between 2013 and 2014, the outcomes of 20 soccer players undergoing ACL reconstruction using bone–patellar tendon–bone autograft infiltrated with ADRC at the end of the procedure were compared to a historical, matched cohort of 19 soccer players undergoing the same procedure without ADRC. Outcomes were obtained at baseline, and 6 and 12 months postop for IKDC (International Knee Documentation Committee), Lysholm, and Lequesne, and at 2, 4, 6, and 12 months postop for VAS (visual analogue scale) for pain and graft maturation to evaluate the ligamentization process (magnetic resonance imaging (MRI)-based). Results: Both groups significantly improved the IKDC (p < 0.001 in both groups), Lysholm (p < 0.001 in both groups), Lequesne index (p < 0.001 in both groups), VAS for pain (p = 0.002 for the ADRC and p < 0.001 for the control group), and MRI scores (p < 0.001 in both groups) in the 12 months postop compared to baseline scores. However, there were no significant differences in the improvement of the outcomes between groups across time (p > 0.05). All patients returned to sports after surgery, but 8 (40%) patients in the ADRC and 13 (68.4%) patients in the control group had lower Tegner activity score at 12 months postop. Conclusions: Patients receiving ADRC at the time of ACL reconstruction significantly improved knee function and healing/maturation of the graft at 12 months. However, this improvement was not statistically significant compared to a control group undergoing ACL reconstruction alone.
Document Type
Article
Document version
Accepted version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Cèl·lules mare
Teixit adipós
Ossos -- Empelts
Genolls -- Cirurgia
Ferides i lesions
Esports -- Lesions
Células madre
Tejido adiposo
Injertos óseos
Rodillas -- Cirugía
Heridas y lesiones
Deportes -- Heridas y lesiones
Stem cells
Adipose tissue
Bone -- Grafts
Knee -- Surgery
Wounds and injuries
Sports injuries
Pages
8
Publisher
SAGE Publications
Collection
27; 3
Is part of
Journal of Orthopaedic Surgery
Citation
Alentorn-Geli, Eduard; Seijas, Roberto; Martínez-De la Torre, Adrián [et al.]. Effects of autologous adipose-derived regenerative stem cells administered at the time of anterior cruciate ligament reconstruction on knee function and graft healing. Journal of Orthopaedic Surgery, 2019, 27(3), p. 1-8. Disponible en: <https://journals.sagepub.com/doi/10.1177/2309499019867580>. Fecha de acceso: 27 may. 2020. DOI: 10.1177/2309499019867580.
This item appears in the following Collection(s)
- Ciències de la Salut [740]
Rights
© The Author(s) 2019. Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative CommonsAttribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercialuse, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and OpenAccess pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc/4.0/