dc.contributor.author | Fernandez, Rafael | |
dc.contributor.author | Subirà Cuyàs, Carles | |
dc.contributor.author | Frutos‑Vivar, Fernando | |
dc.contributor.author | Rialp, Gemma | |
dc.contributor.author | Laborda, Cesar | |
dc.contributor.author | Masclans, Joan Ramon | |
dc.contributor.author | Lesmes, Amanda | |
dc.contributor.author | Panadero, Luna | |
dc.contributor.author | Hernandez, Gonzalo | |
dc.date.accessioned | 2020-01-02T15:40:32Z | |
dc.date.available | 2020-01-02T15:40:32Z | |
dc.date.issued | 2017-05-02 | |
dc.identifier.citation | Fernandez, Rafael; Subira, Carles; Frutos‑Vivar, Fernando [et al.]. High-flow nasal cannula to prevent postextubation respiratory failure in high-risk non-hypercapnic patients: a randomized multicenter trial. Annals of Intensive Care, 2017, vol. 7, p. 1-7. Disponible en: <https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-017-0270-9#article-info>. Fecha de acceso: 2 ene. 2020. DOI: 10.1186/s13613-017-0270-9. | ca |
dc.identifier.issn | 2110-5820 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/1414 | |
dc.description.abstract | Background: Extubation failure is associated with increased morbidity and mortality, but cannot be safely predicted or avoided. High-flow nasal cannula (HFNC) prevents postextubation respiratory failure in low-risk patients. Objective: To demonstrate that HFNC reduces postextubation respiratory failure in high-risk non-hypercapnic patients compared with conventional oxygen. Methods: Randomized, controlled multicenter trial in patients who passed a spontaneous breathing trial. We enrolled patients meeting criteria for high-risk of failure to randomly receive HFNC or conventional oxygen for 24 h after extubation. Primary outcome was respiratory failure within 72-h postextubation. Secondary outcomes were reintubation, intensive care unit (ICU) and hospital lengths of stay, and mortality. Statistical analysis included multiple logistic regression models. Results: The study was stopped due to low recruitment after 155 patients were enrolled (78 received high-flow and 77 received conventional oxygen). Groups were similar at enrollment, and all patients tolerated 24-h HFNC. Postextubation respiratory failure developed in 16 (20%) HFNC patients and in 21 (27%) conventional patients [OR 0.69 (0.31–1.54), p = 0.2]. Reintubation was needed in 9 (11%) HFNC patients and in 12 (16%) conventional patients [OR 0.71 (0.25–1.95), p = 0.5]. No difference was found in ICU or hospital length of stay, or mortality. Logistic regression models suggested HFNC [OR 0.43 (0.18–0.99), p = 0.04] and cancer [OR 2.87 (1.04–7.91), p = 0.04] may be independently associated with postextubation respiratory failure. Conclusion: Our study is inconclusive as to a potential benefit of HFNC over conventional oxygen to prevent occurrence of respiratory failure in non-hypercapnic patients at high risk for extubation failure. | ca |
dc.format.extent | 7 | ca |
dc.language.iso | eng | ca |
dc.publisher | Springer Nature | ca |
dc.relation.ispartof | Annals of Intensive Care | ca |
dc.relation.ispartofseries | 7; | |
dc.rights | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Nodrissons--Deslletament | ca |
dc.subject.other | Respiració artificial | |
dc.subject.other | Tràquea--Intubació | |
dc.subject.other | Oxigen | |
dc.subject.other | Neonatos--Alimentación | |
dc.subject.other | Respiración artificial | |
dc.subject.other | Tráquea -- Intubación | |
dc.subject.other | Oxígeno | |
dc.subject.other | Mechanical ventilation (Therapy) | |
dc.subject.other | Weaning | |
dc.subject.other | Intubation | |
dc.subject.other | Oxygen | |
dc.title | High-flow nasal cannula to prevent postextubation respiratory failure in high-risk non-hypercapnic patients: a randomized multicenter trial | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/acceptedVersion | ca |
dc.embargo.terms | cap | ca |
dc.subject.udc | 61 | ca |
dc.identifier.doi | https://dx.doi.org/10.1186/s13613-017-0270-9 | ca |