Show simple item record

dc.contributor.authorDevis, Laura
dc.contributor.authorMartinez-Garcia, Elena
dc.contributor.authorMoiola, Cristian P.
dc.contributor.authorQuiles Pérez, María Teresa
dc.contributor.authorArbós Vilà, Maria Antonia
dc.contributor.authorVasilica Stirbat, Tomita
dc.contributor.authorBrochard-Wyart, Françoise
dc.contributor.authorGarcía, Ángel
dc.contributor.authorAlonso-Alconada, Lorena
dc.contributor.authorAbal, Miguel
dc.contributor.authorDiaz-Feijoo, Berta
dc.contributor.authorThomas, William
dc.contributor.authorDufour, Sylvie
dc.contributor.authorMancebo, Gemma
dc.contributor.authorAlameda, Francesc
dc.contributor.authorReventós, Jaume
dc.contributor.authorGil-Moreno, Antonio
dc.contributor.authorColas, Eva
dc.date.accessioned2019-12-28T15:12:49Z
dc.date.available2019-12-28T15:12:49Z
dc.date.issued2018-03-30
dc.identifier.citationDevis, Laura; Martinez-Garcia, Elena; Moiola, Cristian P. [et al.]. ALCAM shedding at the invasive front of the tumor is a marker of myometrial infiltration and promotes invasion in endometrioid endometrial cancer. Oncotarget, 2018, vol. 9, núm. 24, p. 16648-16664. Disponible en: <http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=24625&path[]=77263>. Fecha de acceso: 28 dic. 2019. DOI: 10.18632/oncotarget.24625.ca
dc.identifier.issn1949-2553ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/1410
dc.description.abstractEndometrial cancer (EC) is the sixth deadliest cancer in women. The depth of myometrial invasion is one of the most important prognostic factors, being directly associated with tumor recurrence and mortality. In this study, ALCAM, a previously described marker of EC recurrence, was studied by immunohistochemistry at the superficial and the invasive tumor areas from 116 EC patients with different degree of myometrial invasion and related to a set of relevant epithelial and mesenchymal markers. ALCAM expression presented a heterogeneous functionality depending on its localization, it correlated with epithelial markers (E-cadherin/β-catenin) at the superficial area, and with mesenchymal markers at the invasive front (COX-2, SNAIL, ETV5, and MMP-9). At the invasive front, ALCAM-negativity was an independent marker of myometrial invasion. This negativity, together with an increase of soluble ALCAM in uterine aspirates from patients with an invasive EC, and its positive correlation with MMP-9 levels, suggested that ALCAM shedding by MMP-9 occurs at the invasive front. In vivo and in vitro models of invasive EC were generated by ETV5-overexpression. In those, we demonstrated that ALCAM shedding was related to a more invasive pattern and that full-ALCAM recovery reverted most of the ETV5-cells mesenchymal abilities, partially through a p-ERK dependent-manner.ca
dc.format.extent17ca
dc.language.isoengca
dc.publisherImpact Journalsca
dc.relation.ispartofOncotargetca
dc.relation.ispartofseries9;24
dc.rightsDevis et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ca
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.subject.otherEndometri--Càncerca
dc.subject.otherCitoplasma
dc.subject.otherTumors
dc.subject.otherEndometrio--Cáncer
dc.subject.otherCitogenética
dc.subject.otherTumores
dc.subject.otherEndometriosis--Cancer
dc.subject.otherMyometrium
dc.subject.otherCytoplasm
dc.subject.otherTumors
dc.titleALCAM shedding at the invasive front of the tumor is a marker of myometrial infiltration and promotes invasion in endometrioid endometrial cancerca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/acceptedVersionca
dc.embargo.termscapca
dc.subject.udc61ca
dc.identifier.doihttps://dx.doi.org/10.18632/oncotarget.24625ca


Files in this item

 

This item appears in the following Collection(s)

Show simple item record

Devis et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source
are credited.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/3.0/