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dc.contributor.authorFernandez, Rafael
dc.contributor.authorCano Hernandez, Silvia
dc.contributor.authorCatalan, Ignacio
dc.contributor.authorRubio Sanchiz, Olga
dc.contributor.authorSubirà Cuyàs, Carles
dc.contributor.authorMasclans, Jaume
dc.contributor.authorRognoni, Gina
dc.contributor.authorVentura, Lara
dc.contributor.authorMacharete, Caroline
dc.contributor.authorWinfield, Len
dc.contributor.authorAlcoverro, Josep Mª.
dc.date.accessioned2019-12-22T18:52:57Z
dc.date.available2019-12-22T18:52:57Z
dc.date.issued2018-11-16
dc.identifier.citationFernandez, Rafael; Cano, Silvia; Catalan, Ignacio [et al.]. High red blood cell distribution width as a marker of hospital mortality after ICU discharge: a cohort study. Journal of Intensive Care, 2018, vol. 6, p. 1-7. Disponible en: <https://jintensivecare.biomedcentral.com/articles/10.1186/s40560-018-0343-3#Ack1>. Fecha de acceso: 22 dic. 2019. DOI: 10.1186/s40560-018-0343-3.ca
dc.identifier.issn2052-0492ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/1405
dc.description.abstractBackground: High red blood cell distribution width (RDW) is associated with worse outcome in diverse scenarios, including in critical illness. The Sabadell score (SS) predicts in-hospital survival after ICU discharge. We aimed to determine RDW’s association with survival after ICU discharge and whether RDW can improve the accuracy of the SS. Design: Retrospective cohort study. Setting: general ICU at a university hospital. Patients: We included all patients discharged to wards from January 2010 to October 2016. Methods: We analyzed associations between RDW and variables recorded on admission (age, comorbidities, severity score), during the ICU stay (treatments, complications, length of stay (LOS)), and at ICU discharge (SS). The primary outcome was hospital mortality. Statistical analysis included multivariable logistic regression and receiver operating characteristic curve (ROC) analyses. Results: We discharged 3366 patients to wards; median ward LOS was 7 [4–13] days; ward mortality was 5.2%. Mean RDW at ICU discharge was 15.4 ± 2.5%. Ward mortality was higher at each quartile of RDW (0.7%, 2.9%, 7.5%, 10.3%; area under ROC 0.81). A logistic regression model with Sabadell score obtained an excellent accuracy for ward mortality (area under ROC 0.863), and the addition of RDW slightly improved accuracy (AUROC 0.890, p < 0.05). Recursive partitioning demonstrated higher mortality in patients with high RDW at each SS level (1.6% vs. 0.3% in SS0, 9.7% vs. 1.1% in SS1, 21.9% vs. 9.7% in SS2), but not in SS3. Conclusion: High RDW is a marker of severity at ICU discharge and improves the accuracy of Sabadell score in predicting ward mortality except in the more extreme SS3.ca
dc.format.extent7ca
dc.language.isoengca
dc.publisherSpringer Natureca
dc.relation.ispartofJournal of Intensive Careca
dc.relation.ispartofseries6;
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.ca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.otherMortalitatca
dc.subject.otherMarcadors bioquímics
dc.subject.otherCèl·lules sanguínies
dc.subject.otherMortalidad
dc.subject.otherMarcadores bioquímicos
dc.subject.otherCélulas sanguíneas
dc.subject.otherMortality
dc.subject.otherBiomarkers
dc.subject.otherBlood cells
dc.titleHigh red blood cell distribution width as a marker of hospital mortality after ICU discharge: a cohort studyca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/acceptedVersionca
dc.embargo.termscapca
dc.subject.udc61ca
dc.identifier.doihttps://dx.doi.org/10.1186/s40560-018-0343-3ca


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This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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