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Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1
(eLife Sciences Publications, 2019-09-13)
Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct
cause-effect relationships are not well understood. We show that most yeast cells arrest in G1
before death with low ...
The transcriptional network activated by Cln3 cyclin at the G1-to-S transition of the yeast cell cycle
(BMC, 2010-06-23)
Background: The G1-to-S transition of the cell cycle in the yeast Saccharomyces cerevisiae involves an extensive
transcriptional program driven by transcription factors SBF (Swi4-Swi6) and MBF (Mbp1-Swi6). ...