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Growth rate as a direct regulator of the start network to set cell size
(Frontiers Media, 2017-05-26)
Cells are able to adjust their growth and size to external inputs to comply with specific
fates and developmental programs. Molecular pathways controlling growth also have
an enormous impact in cell ...
Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1
(eLife Sciences Publications, 2019-09-13)
Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct
cause-effect relationships are not well understood. We show that most yeast cells arrest in G1
before death with low ...