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Growth rate as a direct regulator of the start network to set cell size
(Frontiers Media, 2017-05-26)
Cells are able to adjust their growth and size to external inputs to comply with specific
fates and developmental programs. Molecular pathways controlling growth also have
an enormous impact in cell ...
Nucleosome architecture throughout the cell cycle
(Nature Research, 2016-01-28)
Nucleosomes provide additional regulatory mechanisms to transcription and DNA replication
by mediating the access of proteins to DNA. During the cell cycle chromatin undergoes several
conformational ...
Centromeric signaling proteins boost G1 cyclin degradation and modulate cell size in budding yeast
(Public Library of Science, 2018-08-06)
Cell size scales with ploidy in a great range of eukaryotes, but the underlying mechanisms
remain unknown. Using various orthogonal single-cell approaches, we show that cell size
increases linearly ...
Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress
(Life Science Alliance, 2019-04-15)
The precise coordination of growth and proliferation has a
universal prevalence in cell homeostasis. As a prominent
property, cell size is modulated by the coordination between
these processes in ...
The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation
(Nature Research, 2012-08-21)
Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain a critical size set by external conditions. However, arguing against deterministic models of cell size ...
Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1
(eLife Sciences Publications, 2019-09-13)
Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct
cause-effect relationships are not well understood. We show that most yeast cells arrest in G1
before death with low ...