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Hormone-control regions mediate steroid receptor–dependent genome organization
(Cold Spring Harbor Laboratory Press, 2019)
In breast cancer cells, some topologically associating domains (TADs) behave as hormonal gene regulation units, within which gene transcription is coordinately regulated in response to steroid hormones. ...
Hidden costs in breast cancer-related lymphedema
(Elsevier, 2021)
Breast cancer is the most common neoplastic process in women, with an incidence of 2,088,849 cases in 2018, and an overall 5-year survival of 90% and a 10-year survival of 83%.1 Lymphedema secondary to ...
90 years of progesterone: molecular mechanisms of progesterone receptor action on the breast cancer genome
(Bioscientifica Ltd., 2020)
Gene regulation by steroid hormones has been at the forefront in elucidating the intricacies of transcriptional regulation in eukaryotes ever since the discovery by Karlson and Clever that the insect ...
Correlation between superficial and deep lymphatic systems using magnetic resonance lymphangiography in breast cancer-related lymphedema: clinical implications
(Elsevier, 2020)
Background: Magnetic resonance lymphangiography (MRL) has increased our knowledge of lymphatic anatomy and lymphedema pathophysiology and improved the efficacy of microsurgical procedures to manage ...
Multidisciplinary preventive intervention for breast cancer-related lymphedema: an international consensus
(Wiley, 2022)
Objective: To establish a consensus regarding the multidisciplinary prevention of breast cancer-related lymphedema (BCRL), taking into account the expert opinion of professional groups from across the ...
Signalling network of breast cancer cells in response to progesterone
(Cold Spring Harbor Laboratory, 2020)
Breast cancer cells enter into the cell cycle following progestin exposure by the activation of signalling cascades involving a plethora of enzymes, transcription factors and co-factors that transmit ...
Breast cancer-related lymphoedema: risk factors and prediction model
(Wiley, 2021)
Aims: To identify the risk factors for lymphoedema following axillary lymph node dissection (ALND) in a European sample and to propose a lymphoedema prediction model for this population. Design: Predictive ...
Cpt1c downregulation causes plasma membrane remodelling and anthracycline resistance in breast cancer
(MDPI, 2023)
Breast cancer (BC) is the most common malignancy in women worldwide. While the main systemic treatment option is anthracycline-containing chemotherapy, chemoresistance continues to be an obstacle to ...