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Emergency short-stay unit as an effective alternative to in-hospital admission for acute exacerbation of chronic heart failure
(Scientific Research Publishing, 2014-10)
Study Objective: To determine whether a new emergency department short-stay unit (EDSSU) was an effective alternative to conventional hospital units (HU) for acute exacerbation of chronic heart failure ...
Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation
(Public Library of Science, 2014-06-06)
In response to peripheral nerve injury, Schwann cells adopt a migratory phenotype and modify the extracellular matrix to make it permissive for cell migration and axonal re-growth. Uridine 5′-triphosphate ...
Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance
(Elsevier, 2014-10)
Hypothalamic endoplasmic reticulum (ER) stress is a key mechanism leading to obesity. Here, we demonstrate that ceramides induce lipotoxicity and hypothalamic ER stress, leading to sympathetic inhibition, ...
Distinct structural transitions of chromatin topological domains correlate with coordinated hormone-induced gene regulation
(Cold Spring Harbor Laboratory Press, 2014)
The human genome is segmented into topologically associating domains (TADs), but the role of this conserved organization during transient changes in gene expression is not known. Here we describe the ...
Molecular evolution of multiple-level control of heme biosynthesis pathway in animal kingdom
(Public Library of Science, 2014)
Adaptation of enzymes in a metabolic pathway can occur not only through changes in amino acid sequences but also through variations in transcriptional activation, mRNA splicing and mRNA translation. The ...
A barbed suture repair for flexor tendons: a novel technique with no exposed barbs
(Lippincott, Williams & Wilkins, 2014-10-23)
Background: Barbed suture technology has shown promise in flexor tendon
repairs, as there is an even distribution of load and the need for a knot
is eliminated. We propose that a quick and simple, ...
Functional and clinical impact of novel Tmprss6 variants in iron-refractory iron-deficiency anemia patients and genotype–phenotype studies
(Wiley, 2014)
Iron-refractory iron-deficiency anemia (IRIDA) is a rare autosomal-recessive disorder characterized by hypochromic microcytic anemia, low transferrin saturation, and inappropriate high levels of the ...
Impact of a long-term tobacco-free policy at a comprehensive cancer center: a series of cross-sectional surveys
(Springer Nature, 2014)
Background: Spain has passed two smoke-free laws in the last years. In 2005, the law banned smoking in indoor places, and in 2010 the ban was extended to outdoor areas of certain premises such as ...
High-intensity vs. sham inspiratory muscle training in patients with chronic heart failure: a prospective randomized trial
(Wiley, 2014)
Aims: The purpose of this study was to evaluate the effectiveness, feasibility, and safety of a 4-week high-intensity inspiratory muscle training (hi-IMT) in patients with chronic heart failure (CHF). ...